Rhamy Zeid
Overview
Explore the profile of Rhamy Zeid including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
2104
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0
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Recent Articles
1.
Poon E, Liang T, Jamin Y, Walz S, Kwok C, Hakkert A, et al.
J Clin Invest
. 2020 Oct;
130(11):5875-5892.
PMID: 33016930
The undruggable nature of oncogenic Myc transcription factors poses a therapeutic challenge in neuroblastoma, a pediatric cancer in which MYCN amplification is strongly associated with unfavorable outcome. Here, we show...
2.
Shu S, Wu H, Ge J, Zeid R, Harris I, Jovanovic B, et al.
Mol Cell
. 2020 May;
78(6):1096-1113.e8.
PMID: 32416067
BET bromodomain inhibitors (BBDIs) are candidate therapeutic agents for triple-negative breast cancer (TNBC) and other cancer types, but inherent and acquired resistance to BBDIs limits their potential clinical use. Using...
3.
Hemming M, Lawlor M, Zeid R, Lesluyes T, Fletcher J, Raut C, et al.
Proc Natl Acad Sci U S A
. 2018 Jun;
115(25):E5746-E5755.
PMID: 29866822
Activating mutations in the KIT or PDGFRA receptor tyrosine kinases are hallmarks of gastrointestinal stromal tumor (GIST). The biological underpinnings of recurrence following resection or disease progression beyond kinase mutation...
4.
Zeid R, Lawlor M, Poon E, Reyes J, Fulciniti M, Lopez M, et al.
Nat Genet
. 2018 Jan;
50(4):515-523.
PMID: 29379199
Amplification of the locus encoding the oncogenic transcription factor MYCN is a defining feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and transcriptional landscape of MYCN perturbation...
5.
Cheng J, Park D, Berrios C, White E, Arora R, Yoon R, et al.
PLoS Pathog
. 2017 Oct;
13(10):e1006668.
PMID: 29028833
Merkel cell carcinoma (MCC) frequently contains integrated copies of Merkel cell polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small T antigen (ST)....
6.
Winter G, Mayer A, Buckley D, Erb M, Roderick J, Vittori S, et al.
Mol Cell
. 2017 Jul;
67(1):5-18.e19.
PMID: 28673542
Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human gene control. A small number of regulatory factors influence transcription elongation on...
7.
Erb M, Scott T, Li B, Xie H, Paulk J, Seo H, et al.
Nature
. 2017 Feb;
543(7644):270-274.
PMID: 28241139
Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive acute leukaemia associated with poor clinical outcome. The preferential involvement of chromatin-associated factors as MLL fusion...
8.
Bandopadhayay P, Ramkissoon L, Jain P, Bergthold G, Wala J, Zeid R, et al.
Nat Genet
. 2016 Feb;
48(3):273-82.
PMID: 26829751
Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs, including 19 angiocentric gliomas. We identified...
9.
Lin C, Erkek S, Tong Y, Yin L, Federation A, Zapatka M, et al.
Nature
. 2016 Jan;
530(7588):57-62.
PMID: 26814967
Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating consequences on the developing child. Genomic studies have revealed four distinct molecular subgroups with divergent biology and clinical behaviour....
10.
Bandopadhayay P, Bergthold G, Nguyen B, Schubert S, Gholamin S, Tang Y, et al.
Clin Cancer Res
. 2013 Dec;
20(4):912-25.
PMID: 24297863
Purpose: MYC-amplified medulloblastomas are highly lethal tumors. Bromodomain and extraterminal (BET) bromodomain inhibition has recently been shown to suppress MYC-associated transcriptional activity in other cancers. The compound JQ1 inhibits BET...