Justin M Roberts
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Explore the profile of Justin M Roberts including associated specialties, affiliations and a list of published articles.
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22
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Recent Articles
1.
Cangelosi A, Puszynska A, Roberts J, Armani A, Nguyen T, Spinelli J, et al.
Science
. 2022 Jun;
377(6601):47-56.
PMID: 35771919
The mechanistic target of rapamycin complex 1 (mTORC1) kinase controls growth in response to nutrients, including the amino acid leucine. In cultured cells, mTORC1 senses leucine through the leucine-binding Sestrin...
2.
San Martin R, Das P, Dos Reis Marques R, Xu Y, Roberts J, Sanders J, et al.
J Cell Biol
. 2021 Dec;
221(2).
PMID: 34889941
Prostate cancer aggressiveness and metastatic potential are influenced by gene expression and genomic aberrations, features that can be influenced by the 3D structure of chromosomes inside the nucleus. Using chromosome...
3.
Condon K, Orozco J, Adelmann C, Spinelli J, van der Helm P, Roberts J, et al.
Proc Natl Acad Sci U S A
. 2021 Jan;
118(4).
PMID: 33483422
In mammalian cells, nutrients and growth factors signal through an array of upstream proteins to regulate the mTORC1 growth control pathway. Because the full complement of these proteins has not...
4.
Labanca E, Vazquez E, Corn P, Roberts J, Wang F, Logothetis C, et al.
Endocr Relat Cancer
. 2020 May;
27(7):R255-R265.
PMID: 32369771
Many solid tumors metastasize to bone, but only prostate cancer has bone as a single, dominant metastatic site. Recently, the FGF axis has been implicated in cancer progression in some...
5.
Zhao L, Dunne C, Clausen D, Roberts J, Paulk J, Liu H, et al.
Isr J Chem
. 2019 Feb;
57(3-4):319-330.
PMID: 30760938
The synthesis of biotinylated conjugates of synthetic analogues of the potent and selective histone deacetylase (HDAC) inhibitor largazole is reported. The thiazole moiety of the parent compound's cap group was...
6.
Wang J, Erazo T, Ferguson F, Buckley D, Gomez N, Munoz-Guardiola P, et al.
ACS Chem Biol
. 2018 Aug;
13(9):2438-2448.
PMID: 30102854
Bromodomains have been pursued intensively over the past several years as emerging targets for the development of anticancer and anti-inflammatory agents. It has recently been shown that some kinase inhibitors...
7.
Nabet B, Roberts J, Buckley D, Paulk J, Dastjerdi S, Yang A, et al.
Nat Chem Biol
. 2018 Mar;
14(5):431-441.
PMID: 29581585
Dissection of complex biological systems requires target-specific control of the function or abundance of proteins. Genetic perturbations are limited by off-target effects, multicomponent complexity, and irreversibility. Most limiting is the...
8.
Kalin J, Wu M, Gomez A, Song Y, Das J, Hayward D, et al.
Nat Commun
. 2018 Jan;
9(1):53.
PMID: 29302039
Here we report corin, a synthetic hybrid agent derived from the class I HDAC inhibitor (entinostat) and an LSD1 inhibitor (tranylcypromine analog). Enzymologic analysis reveals that corin potently targets the...
9.
Huang H, Seo H, Zhang T, Wang Y, Jiang B, Li Q, et al.
Elife
. 2017 Sep;
6.
PMID: 28926338
Thorough preclinical target validation is essential for the success of drug discovery efforts. In this study, we combined chemical and genetic perturbants, including the development of a novel selective maternal...
10.
Winter G, Mayer A, Buckley D, Erb M, Roderick J, Vittori S, et al.
Mol Cell
. 2017 Jul;
67(1):5-18.e19.
PMID: 28673542
Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human gene control. A small number of regulatory factors influence transcription elongation on...