Reshma Ramracheya
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Explore the profile of Reshma Ramracheya including associated specialties, affiliations and a list of published articles.
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30
Citations
1912
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Recent Articles
1.
Gandasi N, Gao R, Kothegala L, Pearce A, Santos C, Acreman S, et al.
Diabetologia
. 2023 Dec;
67(3):528-546.
PMID: 38127123
Aims/hypothesis: Diabetes mellitus is associated with impaired insulin secretion, often aggravated by oversecretion of glucagon. Therapeutic interventions should ideally correct both defects. Glucagon-like peptide 1 (GLP-1) has this capability but...
2.
Choong Y, Lim Y, Soong J, Savoo N, Guida C, Rhyman L, et al.
Hormones (Athens)
. 2021 Mar;
20(3):557-569.
PMID: 33782920
Purpose: Diabetes mellitus is a common condition in the clinically obese. Bariatric surgery is one of the ways to put type 2 diabetes in remission. Recent findings propose the appetite-regulator...
3.
Guida C, Ramracheya R
Clin Med Insights Endocrinol Diabetes
. 2020 Feb;
13:1179551419892985.
PMID: 32030069
Metabolic surgery leads to rapid and effective diabetes reversal in humans, by weight-independent mechanisms. The crucial improvement in pancreatic islet function observed after surgery is induced by alteration in several...
4.
Vergari E, Denwood G, Salehi A, Zhang Q, Adam J, Alrifaiy A, et al.
Nat Metab
. 2020 Jan;
2(1):32-40.
PMID: 31993555
Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon...
5.
Dwivedi O, Lehtovirta M, Hastoy B, Chandra V, Krentz N, Kleiner S, et al.
Nat Genet
. 2019 Nov;
51(11):1596-1606.
PMID: 31676859
A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited relatives of the...
6.
Denwood G, Tarasov A, Salehi A, Vergari E, Ramracheya R, Takahashi H, et al.
J Gen Physiol
. 2019 Jul;
151(9):1094-1115.
PMID: 31358556
Somatostatin secretion from pancreatic islet δ-cells is stimulated by elevated glucose levels, but the underlying mechanisms have only partially been elucidated. Here we show that glucose-induced somatostatin secretion (GISS) involves...
7.
Vergari E, Knudsen J, Ramracheya R, Salehi A, Zhang Q, Adam J, et al.
Nat Commun
. 2019 Jan;
10(1):139.
PMID: 30635569
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of...
8.
Knudsen J, Hamilton A, Ramracheya R, Tarasov A, Brereton M, Haythorne E, et al.
Cell Metab
. 2018 Nov;
29(2):430-442.e4.
PMID: 30415925
Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion...
9.
Ramracheya R, Chapman C, Chibalina M, Dou H, Miranda C, Gonzalez A, et al.
Physiol Rep
. 2018 Sep;
6(17):e13852.
PMID: 30187652
Glucagon is the body's main hyperglycemic hormone, and its secretion is dysregulated in type 2 diabetes mellitus (T2DM). The incretin hormone glucagon-like peptide-1 (GLP-1) is released from the gut and...
10.
Olsen M, Johannessen H, Ramracheya R, Zhao C, Chen D
Curr Pharm Des
. 2018 Jun;
24(18):1926-1935.
PMID: 29898650
The number of people who are overweight and obese are continuously increasing both in the adult and adolescent populations. Coinciding with this is the increased prevalence of health problems such...