Frances M Ashcroft
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Explore the profile of Frances M Ashcroft including associated specialties, affiliations and a list of published articles.
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168
Citations
9389
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Recent Articles
1.
Hill T, Gao R, Benrick A, Kothegala L, Rorsman N, Santos C, et al.
Nat Metab
. 2024 Sep;
6(11):2070-2081.
PMID: 39313541
Diabetes mellitus involves both insufficient insulin secretion and dysregulation of glucagon secretion. In healthy people, a fall in plasma glucose stimulates glucagon release and thereby increases counter-regulatory hepatic glucose production....
2.
Burkart M, Kurzke J, Jacobi R, Vera J, Ashcroft F, Eilers J, et al.
Brain
. 2024 May;
147(12):4200-4212.
PMID: 38748482
ATP-sensitive potassium (KATP) channels couple cell metabolism to cellular electrical activity. Humans affected by severe activating mutations in KATP channels suffer from developmental delay, epilepsy and neonatal diabetes (DEND syndrome)....
3.
Vedovato N, Salguero M, Greeley S, Yu C, Philipson L, Ashcroft F
Diabetologia
. 2024 Feb;
67(5):940-951.
PMID: 38366195
Aims/hypothesis: The ATP-sensitive potassium (K) channel couples beta cell electrical activity to glucose-stimulated insulin secretion. Loss-of-function mutations in either the pore-forming (inwardly rectifying potassium channel 6.2 [Kir6.2], encoded by KCNJ11)...
4.
Ashcroft F
Diabetes
. 2023 Oct;
72(6):693-702.
PMID: 37815796
Diabetes is characterized by elevation of plasma glucose due to an insufficiency of the hormone insulin and is associated with both inadequate insulin secretion and impaired insulin action. The Banting...
5.
Pipatpolkai T, Corey R, Proks P, Ashcroft F, Stansfeld P
Commun Chem
. 2023 Jan;
3(1):147.
PMID: 36703430
Membrane proteins are frequently modulated by specific protein-lipid interactions. The activation of human inward rectifying potassium (hKir) channels by phosphoinositides (PI) has been well characterised. Here, we apply a coarse-grained...
6.
Ashcroft F, Lloyd M, Haythorne E
Trends Endocrinol Metab
. 2022 Dec;
34(2):119-130.
PMID: 36586779
Type 2 diabetes (T2D) is a global health problem characterised by chronic hyperglycaemia due to inadequate insulin secretion. Because glucose must be metabolised to stimulate insulin release it was initially...
7.
Haythorne E, Lloyd M, Walsby-Tickle J, Tarasov A, Sandbrink J, Portillo I, et al.
Nat Commun
. 2022 Nov;
13(1):6754.
PMID: 36376280
Chronic hyperglycaemia causes a dramatic decrease in mitochondrial metabolism and insulin content in pancreatic β-cells. This underlies the progressive decline in β-cell function in diabetes. However, the molecular mechanisms by...
8.
Pipatpolkai T, Usher S, Vedovato N, Ashcroft F, Stansfeld P
J Physiol
. 2022 Sep;
600(20):4503-4519.
PMID: 36047384
ATP-sensitive potassium (K ) channels couple the intracellular ATP concentration to insulin secretion. K channel activity is inhibited by ATP binding to the Kir6.2 tetramer and activated by phosphatidylinositol 4,5-bisphosphate...
9.
Koberstein J, Stewart M, Smith C, Tarasov A, Ashcroft F, Stork P, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(31):e2204407119.
PMID: 35881794
Cellular metabolism is regulated over space and time to ensure that energy production is efficiently matched with consumption. Fluorescent biosensors are useful tools for studying metabolism as they enable real-time...
10.
Sachse G, Haythorne E, Proks P, Stewart M, Cater H, Ellard S, et al.
Wellcome Open Res
. 2021 Aug;
5:15.
PMID: 34368464
The K channel plays a key role in glucose homeostasis by coupling metabolically generated changes in ATP to insulin secretion from pancreatic beta-cells. Gain-of-function mutations in either the pore-forming (Kir6.2)...