Margarita V Chibalina
Overview
Explore the profile of Margarita V Chibalina including associated specialties, affiliations and a list of published articles.
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24
Citations
935
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Recent Articles
1.
Gandasi N, Gao R, Kothegala L, Pearce A, Santos C, Acreman S, et al.
Diabetologia
. 2023 Dec;
67(3):528-546.
PMID: 38127123
Aims/hypothesis: Diabetes mellitus is associated with impaired insulin secretion, often aggravated by oversecretion of glucagon. Therapeutic interventions should ideally correct both defects. Glucagon-like peptide 1 (GLP-1) has this capability but...
2.
Armour S, Frueh A, Chibalina M, Dou H, Argemi-Muntadas L, Hamilton A, et al.
Diabetes
. 2023 Jul;
72(10):1446-1459.
PMID: 37494670
Article Highlights: It has become clear that dysregulation of glucagon secretion and α-cell function plays an important role in the development of diabetes, but we do not know how glucagon...
3.
Vergari E, Denwood G, Salehi A, Zhang Q, Adam J, Alrifaiy A, et al.
Nat Metab
. 2020 Jan;
2(1):32-40.
PMID: 31993555
Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon...
4.
Vergari E, Knudsen J, Ramracheya R, Salehi A, Zhang Q, Adam J, et al.
Nat Commun
. 2019 Jan;
10(1):139.
PMID: 30635569
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of...
5.
Hastoy B, Godazgar M, Clark A, Nylander V, Spiliotis I, van de Bunt M, et al.
Sci Rep
. 2018 Nov;
8(1):16994.
PMID: 30451893
Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used by the research community. However,...
6.
Knudsen J, Hamilton A, Ramracheya R, Tarasov A, Brereton M, Haythorne E, et al.
Cell Metab
. 2018 Nov;
29(2):430-442.e4.
PMID: 30415925
Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion...
7.
Briant L, Dodd M, Chibalina M, Rorsman N, Johnson P, Carmeliet P, et al.
Cell Rep
. 2018 Jun;
23(11):3300-3311.
PMID: 29898400
Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand...
8.
Godazgar M, Zhang Q, Chibalina M, Rorsman P
J Physiol
. 2018 Feb;
596(9):1601-1626.
PMID: 29441586
Key Points: Na current inactivation is biphasic in insulin-secreting cells, proceeding with two voltage dependences that are half-maximal at ∼-100 mV and -60 mV. Inactivation of voltage-gated Na (Na )...
9.
Adam J, Ramracheya R, Chibalina M, Ternette N, Hamilton A, Tarasov A, et al.
Cell Rep
. 2017 Sep;
20(13):3135-3148.
PMID: 28954230
We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6-8 ...
10.
MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics
Masters T, Tumbarello D, Chibalina M, Buss F
Cell Rep
. 2017 Jun;
19(10):2088-2101.
PMID: 28591580
APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC...