Renaud Wagner
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Explore the profile of Renaud Wagner including associated specialties, affiliations and a list of published articles.
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40
Citations
411
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Recent Articles
1.
Zuniga D, Zoumpoulakis A, Veloso R, Peverini L, Shi S, Pozza A, et al.
FASEB J
. 2024 Nov;
38(21):e70146.
PMID: 39520289
Inwardly rectifying potassium (Kir) channels play a pivotal role in physiology by establishing, maintaining, and regulating the resting membrane potential of the cells, particularly contributing to the cellular repolarization of...
2.
Vidal F, Deloche A, Zeder-Lutz G, Hideux M, Wagner R, Dugas V, et al.
Molecules
. 2024 Jun;
29(12).
PMID: 38930880
Miniaturized weak affinity chromatography is emerging as an interesting alternative to conventional biophysical tools for performing fragment-screening studies in the context of fragment-based drug discovery. In order to push back...
3.
Schwob M, Kugler V, Wagner R
Curr Protoc
. 2023 Nov;
3(11):e936.
PMID: 37933574
Understanding the structure and function of key proteins located within biological membranes is essential for fundamental knowledge and therapeutic applications. Robust cell systems allowing their actual overexpression are required, among...
4.
Deloche A, Vidal F, Jammas L, Wagner R, Dugas V, Demesmay C
Molecules
. 2023 Oct;
28(20).
PMID: 37894592
The identification of weak-affinity ligands targeting membrane proteins is of great interest in Fragment-Based Drug Design (FBDD). Recently, miniaturized weak affinity chromatography (WAC) has been proposed as a valuable tool...
5.
Zeder-Lutz G, Bornert O, Fellmann-Clauss R, Knittel-Obrecht A, Tranchant T, Bouteben S, et al.
Anal Biochem
. 2023 Feb;
665:115062.
PMID: 36731712
G protein-coupled receptor associated sorting protein 1 (GPRASP1) belongs to a family of 10 proteins that display sequence homologies in their C-terminal region. Several members including GPRASP1 also display a...
6.
Boutin J, Logez C, Damian M, Wagner R, Baneres J, Ferry G
Methods Mol Biol
. 2022 Sep;
2550:171-178.
PMID: 36180690
A way to study G protein-coupled receptors in a minimal system is to reconstruct artificial membrane mimics, made of detergent and/or of lipids in which the purified receptor is maintained....
7.
Fernandes C, Zuniga D, Fagnen C, Kugler V, Scala R, Pehau-Arnaudet G, et al.
Sci Adv
. 2022 Sep;
8(38):eabq8489.
PMID: 36149965
We present the first structure of the human Kir2.1 channel containing both transmembrane domain (TMD) and cytoplasmic domain (CTD). Kir2.1 channels are strongly inward-rectifying potassium channels that play a key...
8.
Barret L, Schubeis T, Kugler V, Guyot L, Pintacuda G, Wagner R
Methods Mol Biol
. 2022 Jun;
2507:201-221.
PMID: 35773584
Membrane proteins (MPs) comprise about one-third of the human proteome, playing critical roles in many physiological processes and associated disorders. Consistently, they represent one of the largest classes of targets...
9.
Mustafa E, Cordisco Gonzalez S, Damian M, Cantel S, Denoyelle S, Wagner R, et al.
Front Pharmacol
. 2021 Aug;
12:712437.
PMID: 34447311
The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such...
10.
Lecas L, Hartmann L, Caro L, Mohamed-Bouteben S, Raingeval C, Krimm I, et al.
Anal Chim Acta
. 2020 Apr;
1113:26-35.
PMID: 32340666
Biophysical techniques that enable the screening and identification of weak affinity fragments against a target protein are at the heart of Fragment Based Drug Design approaches. In the case of...