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Renata P Lerner

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Articles 7
Citations 156
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Recent Articles
1.
Franich N, Hickey M, Zhu C, Osborne G, Ali N, Chu T, et al.
J Neurosci Res . 2019 Jul; 97(12):1590-1605. PMID: 31282030
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such...
2.
Lerner R, Francardo V, Fujita K, Bimpisidis Z, Jourdain V, Tang C, et al.
Sci Rep . 2017 Nov; 7(1):16005. PMID: 29167476
Chronic levodopa treatment leads to the appearance of dyskinesia in the majority of Parkinson's disease patients. Neurovascular dysregulation in putaminal and pallidal regions is thought to be an underlying feature...
3.
Lerner R, Bimpisidis Z, Agorastos S, Scherrer S, Dewey S, Cenci M, et al.
Neurobiol Dis . 2016 Aug; 96:31-37. PMID: 27544483
Dissociation of vasomotor and metabolic responses to levodopa has been observed in human subjects with Parkinson's disease (PD) studied with PET and in autoradiograms from 6-hydroxydopamine (6-OHDA) rat. In both...
4.
Ko J, Lerner R, Eidelberg D
Mov Disord . 2014 Oct; 30(1):54-63. PMID: 25296957
Levodopa (L-dopa) has been at the forefront of antiparkinsonian therapy for a half century. Recent advances in functional brain imaging have contributed substantially to the understanding of the effects of...
5.
Lerner R, Niethammer M, Eidelberg D
Curr Neurol Neurosci Rep . 2013 Oct; 13(11):401. PMID: 24114145
The dystonias comprise a group of syndromes characterized by prolonged involuntary muscle contractions resulting in repetitive movements and abnormal postures. Primary dystonia has been associated with over 14 different genotypes,...
6.
Hickey M, Zhu C, Medvedeva V, Lerner R, Patassini S, Franich N, et al.
Mol Neurodegener . 2012 Apr; 7:12. PMID: 22475209
Background: No disease modifying treatment currently exists for Huntington's disease (HD), a fatal neurodegenerative disorder characterized by the formation of amyloid-like aggregates of the mutated huntingtin protein. Curcumin is a...
7.
Lerner R, Trejo Martinez L, Zhu C, Chesselet M, Hickey M
Brain Res Bull . 2012 Feb; 87(6):571-8. PMID: 22326483
Huntington's disease (HD) is a progressive neurodegenerative disease characterized by progressive atrophy of the striatum, cerebral cortex, and white matter tracks. Major pathological hallmarks of HD include neuronal loss, primarily...