Remigiusz Worch
Overview
Explore the profile of Remigiusz Worch including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
282
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Recent Articles
1.
Mechanochemical consequences of myopathy-linked mutations in Tpm2.2 on striated muscle contractility
Kucukdogru R, Franz P, Worch R, Robaszkiewicz K, Siatkowska M, Tsiavaliaris G, et al.
FASEB J
. 2023 Dec;
38(1):e23400.
PMID: 38156416
Tropomyosin (Tpm) is an actin-binding protein central to muscle contraction regulation. The Tpm sequence consists of periodic repeats corresponding to seven actin-binding sites, further divided in two functionally distinct halves....
2.
Tse W, Pochwat B, Szewczyk B, Misztak P, Bobula B, Tokarski K, et al.
Neuropharmacology
. 2023 Oct;
241:109729.
PMID: 37797736
In the search for new options for the pharmacological treatment of major depressive disorder, compounds with a rapid onset of action and high efficacy but lacking a psychotomimetic effect are...
3.
Kruk P, Nader K, Skupien-Jaroszek A, Wojtowicz T, Buszka A, Olech-Kochanczyk G, et al.
Cells
. 2023 Jun;
12(11).
PMID: 37296604
Background: Epilepsy affects millions of people worldwide, yet we still lack a successful treatment for all epileptic patients. Most of the available drugs modulate neuronal activity. Astrocytes, the most abundant...
4.
Siekierska I, Lukaszewicz M, Worch R, Jankowska-Anyszka M, Piecyk K
ChemMedChem
. 2023 Jan;
18(4):e202200490.
PMID: 36658701
Aryloxy triester phosphoramidate methodology, commonly known as ProTide technology, is one of the most widely used prodrug approaches applied to therapeutic nucleosides. This approach has been used extensively by the...
5.
Kubiszewski-Jakubiak S, Worch R
Virology
. 2022 Mar;
570:1-8.
PMID: 35306415
Enveloped viruses such as Coronaviridae (CoV) enter the host cell by fusing the viral envelope directly with the plasma membrane (PM) or with the membrane of the endosome. Replication of...
6.
Worch R, Dudek A, Borkowska P, Setny P
Int J Mol Sci
. 2021 Jun;
22(10).
PMID: 34069905
Fusion of viral and host cell membranes is a critical step in the life cycle of enveloped viruses. In the case of influenza virus, it is mediated by subunit 2...
7.
Slawski J, Bialek R, Burdzinski G, Gibasiewicz K, Worch R, Grzyb J
J Phys Chem B
. 2021 Mar;
125(13):3307-3320.
PMID: 33760623
Colloidal quantum dots (QDs) are nanoparticles that are able to photoreduce redox proteins by electron transfer (ET). QDs are also able to transfer energy by resonance energy transfer (RET). Here,...
8.
Kubiszewski-Jakubiak S, Worch R
Viruses
. 2020 Dec;
12(12).
PMID: 33348831
Hemagglutinin (HA) is a class I viral membrane fusion protein, which is the most abundant transmembrane protein on the surface of influenza A virus (IAV) particles. HA plays a crucial...
9.
Piecyk K, Pietrow P, Arnold T, Worch R, Korneeva N, Jankowska-Anyszka M
Bioconjug Chem
. 2020 Apr;
31(4):1156-1166.
PMID: 32227927
The development of targeted anticancer drugs has been one of the most challenging goals of current research. Eukaryotic translation initiation factor 4E (eIF4E) is an oncogene that stimulates mRNA translation...
10.
Sztatelman O, Kopec K, Pedziwiatr M, Trojnar M, Worch R, Wielgus-Kutrowska B, et al.
Biochimie
. 2019 Sep;
167:93-105.
PMID: 31560933
In this study, we tested the possibility of creating complexes of two proteins by fusing them with heterodimerizing helices. We used the fluorescent proteins GFP and mCHERRY expressed with a...