Rebecca Gupte
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Explore the profile of Rebecca Gupte including associated specialties, affiliations and a list of published articles.
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9
Citations
681
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Recent Articles
1.
Gupte R, Lin K, Nandu T, Lea J, Kraus W
Mol Cancer Res
. 2022 May;
20(8):1183-1192.
PMID: 35503086
Implications: Our observations, which link the gene regulatory effects of PARPi + cisplatin to the growth inhibitory effects of FOS expression in cervical cancer cells, strengthen the rationale for using...
2.
Szanto M, Gupte R, Kraus W, Pacher P, Bai P
Prog Lipid Res
. 2021 Aug;
84:101117.
PMID: 34450194
PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases were originally identified as DNA repair factors, nevertheless, recent advances have shed light on their role in...
3.
Gupte R, Nandu T, Kraus W
Nat Commun
. 2021 Jun;
12(1):3931.
PMID: 34168143
STAT1α is a key transcription factor driving pro-inflammatory responses in macrophages. We found that the interferon gamma (IFNγ)-regulated transcriptional program in macrophages is controlled by ADP-ribosylation (ADPRylation) of STAT1α, a...
4.
Gupte R, Liu Z, Kraus W
Genes Dev
. 2017 Feb;
31(2):101-126.
PMID: 28202539
The discovery of poly(ADP-ribose) >50 years ago opened a new field, leading the way for the discovery of the poly(ADP-ribose) polymerase (PARP) family of enzymes and the ADP-ribosylation reactions that...
5.
Luo X, Ryu K, Kim D, Nandu T, Medina C, Gupte R, et al.
Mol Cell
. 2017 Jan;
65(2):260-271.
PMID: 28107648
Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins mediated by PARP family members, such as PARP-1. Although PARylation has been studied extensively, few examples of definitive biological roles for site-specific...
6.
Glucocorticoid receptor coordinates transcription factor-dominated regulatory network in macrophages
Chinenov Y, Coppo M, Gupte R, Sacta M, Rogatsky I
BMC Genomics
. 2014 Aug;
15:656.
PMID: 25099603
Background: Inflammation triggered by infection or injury is tightly controlled by glucocorticoid hormones which signal via a dedicated transcription factor, the Glucocorticoid Receptor (GR), to regulate hundreds of genes. However,...
7.
Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle
Gupte R, Muse G, Chinenov Y, Adelman K, Rogatsky I
Proc Natl Acad Sci U S A
. 2013 Aug;
110(36):14616-21.
PMID: 23950223
Widespread anti-inflammatory actions of glucocorticoid hormones are mediated by the glucocorticoid receptor (GR), a ligand-dependent transcription factor of the nuclear receptor superfamily. In conjunction with its corepressor GR-interacting protein-1 (GRIP1),...
8.
Chinenov Y, Gupte R, Rogatsky I
Mol Cell Endocrinol
. 2013 Apr;
380(1-2):55-64.
PMID: 23623868
Inflammation is a protective response of organisms to pathogens, irritation or injury. Primary inflammatory sensors activate an array of signaling pathways that ultimately converge upon a few transcription factors such...
9.
Chinenov Y, Gupte R, Dobrovolna J, Flammer J, Liu B, Michelassi F, et al.
Proc Natl Acad Sci U S A
. 2012 Jul;
109(29):11776-81.
PMID: 22753499
Inhibition of cytokine gene expression by the hormone-activated glucocorticoid receptor (GR) is the key component of the anti-inflammatory actions of glucocorticoids, yet the underlying molecular mechanisms remain obscure. Here we...