Raymond T Doty
Overview
Explore the profile of Raymond T Doty including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
14
Citations
391
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ri K, Weng T, Cabezudo A, Josting W, Zhang Y, Bazzone A, et al.
Nature
. 2024 May;
630(8016):501-508.
PMID: 38778100
Human feline leukaemia virus subgroup C receptor-related proteins 1 and 2 (FLVCR1 and FLVCR2) are members of the major facilitator superfamily. Their dysfunction is linked to several clinical disorders, including...
2.
GAGE-seq concurrently profiles multiscale 3D genome organization and gene expression in single cells
Zhou T, Zhang R, Jia D, Doty R, Munday A, Gao D, et al.
Nat Genet
. 2024 May;
56(8):1701-1711.
PMID: 38744973
The organization of mammalian genomes features a complex, multiscale three-dimensional (3D) architecture, whose functional significance remains elusive because of limited single-cell technologies that can concurrently profile genome organization and transcriptional...
3.
Zhou T, Zhang R, Jia D, Doty R, Munday A, Gao D, et al.
bioRxiv
. 2023 Aug;
PMID: 37546900
The organization of mammalian genomes within the nucleus features a complex, multiscale three-dimensional (3D) architecture. The functional significance of these 3D genome features, however, remains largely elusive due to limited...
4.
Doty R, Lausted C, Munday A, Yang Z, Yan X, Meng C, et al.
Blood Adv
. 2023 Jun;
7(17):4848-4868.
PMID: 37352261
The anemias of myelodysplastic syndrome (MDS) and Diamond Blackfan anemia (DBA) are generally macrocytic and always reflect ineffective erythropoiesis yet result from diverse genetic mutations. To delineate shared mechanisms that...
5.
Doty R, Fan X, Young D, Liang J, Singh K, Pakbaz Z, et al.
Blood
. 2022 Mar;
139(23):3439-3449.
PMID: 35349664
We follow a patient with Diamond-Blackfan anemia (DBA) mosaic for a pathogenic RPS19 haploinsufficiency mutation with persistent transfusion-dependent anemia. Her anemia remitted on eltrombopag (EPAG), but surprisingly, mosaicism was unchanged,...
6.
Doty R, Yan X, Meng C, Lausted C, Tian Q, Abkowitz J
Exp Hematol
. 2021 Feb;
97:66-78.e6.
PMID: 33631277
Rpl11 haploinsufficient mice develop a macrocytic anemia similar to patients with DBA. Here, we fully characterize this model from clinical and pathophysiological perspectives. Early erythroid precursors have increased heme content...
7.
Doty R, Yan X, Lausted C, Munday A, Yang Z, Yi D, et al.
Blood
. 2018 Dec;
133(5):457-469.
PMID: 30530752
Erythropoiesis is the complex, dynamic, and tightly regulated process that generates all mature red blood cells. To understand this process, we mapped the developmental trajectories of progenitors from wild-type, erythropoietin-treated,...
8.
Doty R, Phelps S, Shadle C, Sanchez-Bonilla M, Keel S, Abkowitz J
J Clin Invest
. 2015 Nov;
125(12):4681-91.
PMID: 26551679
Erythropoiesis requires rapid and extensive hemoglobin production. Heme activates globin transcription and translation; therefore, heme synthesis must precede globin synthesis. As free heme is a potent inducer of oxidative damage,...
9.
Byon J, Chen J, Doty R, Abkowitz J
Blood
. 2013 Sep;
122(16):2903-10.
PMID: 24021674
Heme is a pleiotropic molecule that is important for oxygen and oxidative metabolism, most notably as the prosthetic group of hemoglobin and cytochromes. Because excess free intracellular heme is toxic,...
10.
Yang Z, Philips J, Doty R, Giraudi P, Ostrow J, Tiribelli C, et al.
J Biol Chem
. 2010 Jul;
285(37):28874-82.
PMID: 20610401
The feline leukemia virus subgroup C receptor (FLVCR) is a heme export protein that is required for proerythroblast survival and facilitates macrophage heme iron recycling. However, its mechanism of heme...