Janis L Abkowitz
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Explore the profile of Janis L Abkowitz including associated specialties, affiliations and a list of published articles.
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69
Citations
1921
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Recent Articles
1.
Ri K, Weng T, Cabezudo A, Josting W, Zhang Y, Bazzone A, et al.
Nature
. 2024 May;
630(8016):501-508.
PMID: 38778100
Human feline leukaemia virus subgroup C receptor-related proteins 1 and 2 (FLVCR1 and FLVCR2) are members of the major facilitator superfamily. Their dysfunction is linked to several clinical disorders, including...
2.
GAGE-seq concurrently profiles multiscale 3D genome organization and gene expression in single cells
Zhou T, Zhang R, Jia D, Doty R, Munday A, Gao D, et al.
Nat Genet
. 2024 May;
56(8):1701-1711.
PMID: 38744973
The organization of mammalian genomes features a complex, multiscale three-dimensional (3D) architecture, whose functional significance remains elusive because of limited single-cell technologies that can concurrently profile genome organization and transcriptional...
3.
Kopmar N, Quach K, Gooley T, Martino C, Cherian S, Percival M, et al.
JAMA Oncol
. 2024 May;
10(7):961-965.
PMID: 38722664
Importance: Options for adults with relapsed or refractory B-cell acute lymphoblastic leukemia or lymphoma (B-ALL) are limited, and new approaches are needed. Inotuzumab ozogamicin (InO) has been combined with low-intensity...
4.
Duncan B, Lotter J, Superata J, Barranta M, Machado T, Darden I, et al.
Br J Haematol
. 2024 Mar;
204(5):2077-2085.
PMID: 38462764
Diamond-Blackfan anaemia (DBA) is a rare, inherited bone marrow failure syndrome with a ribosomal defect causing slowed globin chain production with normal haem synthesis, causing an overabundance of reactive iron/haem...
5.
Zhou T, Zhang R, Jia D, Doty R, Munday A, Gao D, et al.
bioRxiv
. 2023 Aug;
PMID: 37546900
The organization of mammalian genomes within the nucleus features a complex, multiscale three-dimensional (3D) architecture. The functional significance of these 3D genome features, however, remains largely elusive due to limited...
6.
Doty R, Lausted C, Munday A, Yang Z, Yan X, Meng C, et al.
Blood Adv
. 2023 Jun;
7(17):4848-4868.
PMID: 37352261
The anemias of myelodysplastic syndrome (MDS) and Diamond Blackfan anemia (DBA) are generally macrocytic and always reflect ineffective erythropoiesis yet result from diverse genetic mutations. To delineate shared mechanisms that...
7.
Halpern A, Rodriguez-Arboli E, Othus M, Garcia K, Percival M, Cassaday R, et al.
Blood Adv
. 2023 Jun;
7(17):4950-4961.
PMID: 37339483
The multikinase inhibitor sorafenib improves event-free survival (EFS) when used with 7 + 3 in adults with newly-diagnosed acute myeloid leukemia (AML), irrespective of the FLT3-mutation status. Here, we evaluated...
8.
Cooper J, Abkowitz J
Blood
. 2022 Nov;
141(10):1136-1146.
PMID: 36395067
Acute graft-versus-host disease (GVHD) is a rare complication after solid organ transplantation (SOT) that carries high mortality. Caused by immunocompetent donor leukocytes within the transplanted organ, which become activated against...
9.
Godwin C, Rodriguez-Arboli E, Othus M, Halpern A, Appelbaum J, Percival M, et al.
Cancers (Basel)
. 2022 Jun;
14(12).
PMID: 35740603
Gemtuzumab ozogamicin (GO) improves outcomes when added to intensive AML chemotherapy. A meta-analysis suggested the greatest benefit when combining fractionated doses of GO (GO3) with 7 + 3. To test...
10.
Stolla M, Reilly A, Bergantinos R, Stewart S, Thom N, Clough C, et al.
Blood Adv
. 2022 Apr;
6(12):3579-3589.
PMID: 35443024
Autophagy is a self-degradation pathway that is essential for erythropoiesis. During erythroid differentiation, autophagy facilitates the degradation of macromolecules and the programmed clearance of mitochondria. Impaired mitochondrial clearance results in...