Josbert M Metselaar
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Explore the profile of Josbert M Metselaar including associated specialties, affiliations and a list of published articles.
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84
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1919
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Recent Articles
1.
Mihyar R, Shalmani A, Wildt V, Sheybanifard M, Wang A, May J, et al.
J Control Release
. 2024 Sep;
375:614-626.
PMID: 39316925
Controlled manufacturing and long-term stability are key challenges in the development and translation of nanomedicines. This is exemplified by the mRNA-nanoparticle vaccines against COVID-19, which require (ultra-)cold temperatures for storage...
2.
Shalmani A, Wang A, Ahmed Z, Sheybanifard M, Mihyar R, Buhl E, et al.
Drug Deliv Transl Res
. 2023 Nov;
14(10):2642-2654.
PMID: 37962836
Nanomedicine holds promise for potentiating drug combination therapies. Increasing (pre)clinical evidence is available exemplifying the value of co-formulating and co-delivering different drugs in modular nanocarriers. Taxanes like paclitaxel (PTX) are...
3.
Shalmani A, Ahmed Z, Sheybanifard M, Wang A, Weiler M, Buhl E, et al.
Biomacromolecules
. 2023 Feb;
24(10):4444-4453.
PMID: 36753733
Polymeric micelles are among the most extensively used drug delivery systems. Key properties of micelles, such as size, size distribution, drug loading, and drug release kinetics, are crucial for proper...
4.
Sheybanifard M, Guerzoni L, Omidinia-Anarkoli A, De Laporte L, Buyel J, Besseling R, et al.
Lab Chip
. 2022 Nov;
23(1):182-194.
PMID: 36448477
Continuous flow manufacturing (CFM) has shown remarkable advantages in the industrial-scale production of drug-loaded nanomedicines, including mRNA-based COVID-19 vaccines. Thus far, CFM research in nanomedicine has mainly focused on the...
5.
Roemhild K, Besse H, Wang B, Pena Q, Sun Q, Omata D, et al.
Theranostics
. 2022 Jul;
12(10):4791-4801.
PMID: 35832083
Enzyme-activatable prodrugs are extensively employed in oncology and beyond. Because enzyme concentrations and their (sub)cellular compartmentalization are highly heterogeneous in different tumor types and patients, we propose ultrasound-directed enzyme-prodrug therapy...
6.
Pena Q, Wang A, Zaremba O, Shi Y, Scheeren H, Metselaar J, et al.
Chem Soc Rev
. 2022 Mar;
51(7):2544-2582.
PMID: 35262108
Metal complexes are extensively used for cancer therapy. The multiple variables available for tuning (metal, ligand, and metal-ligand interaction) offer unique opportunities for drug design, and have led to a...
7.
Ferreira-Silva M, Faria-Silva C, Carvalheiro M, Simoes S, Marinho H, Marcelino P, et al.
Pharmaceutics
. 2022 Jan;
14(1).
PMID: 35057000
Ischemia and reperfusion injury (IRI) is a common complication caused by inflammation and oxidative stress resulting from liver surgery. Current therapeutic strategies do not present the desirable efficacy, and severe...
8.
Metselaar J, Middelink L, Wortel C, Bos R, van Laar J, Vonkeman H, et al.
J Control Release
. 2021 Dec;
341:548-554.
PMID: 34896445
Glucocorticoids (GCs) are potent anti-inflammatory drugs but their use is limited by systemic exposure leading to toxicity. Targeted GC delivery to sites of inflammation via encapsulation in long-circulating liposomes may...
9.
Vrouwe J, Kamerling I, van Esdonk M, Metselaar J, Stuurman F, van der Pluijm G, et al.
Pharmacol Res Perspect
. 2021 Aug;
9(5):e00845.
PMID: 34414692
Dexamethasone has antitumor activity in metastatic castration resistant prostate cancer (mCRPC). We aimed to investigate intravenous liposome-encapsulated dexamethasone disodium phosphate (liposomal dexamethasone) administration in mCRPC patients. In this exploratory first-in-man...
10.
van Alem C, Metselaar J, van Kooten C, Rotmans J
Pharmaceutics
. 2021 Aug;
13(7).
PMID: 34371695
Liposomes can be seen as ideal carriers for anti-inflammatory drugs as their ability to (passively) target sites of inflammation and release their content to inflammatory target cells enables them to...