Raphael Rozenfeld
Overview
Explore the profile of Raphael Rozenfeld including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
1387
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0
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Recent Articles
1.
Patel E, Malkova N, Crowe D, Pederzoli-Ribeil M, Fantini D, Fanny M, et al.
Mol Cancer Ther
. 2023 Nov;
23(4):421-435.
PMID: 38030380
IL12 is a proinflammatory cytokine, that has shown promising antitumor activity in humans by promoting the recruitment and activation of immune cells in tumors. However, the systemic administration of IL12...
2.
Yang L, Rozenfeld R, Wu D, Devi L, Zhang Z, Cederbaum A
Free Radic Biol Med
. 2014 Jan;
68:260-7.
PMID: 24398069
Acute alcohol drinking induces steatosis, and effective prevention of steatosis can protect liver from progressive damage caused by alcohol. Increased oxidative stress has been reported as one mechanism underlying alcohol-induced...
3.
Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy
Hernandez-Gea V, Hilscher M, Rozenfeld R, Lim M, Nieto N, Werner S, et al.
J Hepatol
. 2013 Mar;
59(1):98-104.
PMID: 23485523
Background & Aims: Metabolic stress during liver injury enhances autophagy and provokes stellate cell activation, with secretion of scar matrix. Conditions that augment protein synthesis increase demands on the endoplasmic...
4.
Hernandez-Gea V, Ghiassi-Nejad Z, Rozenfeld R, Gordon R, Fiel M, Yue Z, et al.
Gastroenterology
. 2012 Jan;
142(4):938-46.
PMID: 22240484
Background & Aims: The pathogenesis of liver fibrosis involves activation of hepatic stellate cells, which is associated with depletion of intracellular lipid droplets. When hepatocytes undergo autophagy, intracellular lipids are...
5.
Rozenfeld R, Bushlin I, Gomes I, Tzavaras N, Gupta A, Neves S, et al.
PLoS One
. 2012 Jan;
7(1):e29239.
PMID: 22235275
A fundamental question in G protein coupled receptor biology is how a single ligand acting at a specific receptor is able to induce a range of signaling that results in...
6.
Rozenfeld R, Gupta A, Gagnidze K, Lim M, Gomes I, Lee-Ramos D, et al.
EMBO J
. 2011 May;
30(12):2350-63.
PMID: 21540834
The mechanism of G protein-coupled receptor (GPCR) signal integration is controversial. While GPCR assembly into hetero-oligomers facilitates signal integration of different receptor types, cross-talk between Gαi- and Gαq-coupled receptors is...
7.
Rozenfeld R, Devi L
Biochem J
. 2010 Dec;
433(1):11-8.
PMID: 21158738
The critical involvement of GPCRs (G-protein-coupled receptors) in nearly all physiological processes, and the presence of these receptors at the interface between the extracellular and the intracellular milieu, has positioned...
8.
Rozenfeld R
Traffic
. 2010 Nov;
12(1):12-8.
PMID: 21040297
The majority of G-protein-coupled receptors (GPCRs) function at the cell surface, where they are activated by their ligands present in the extracellular milieu. Interestingly, type I cannabinoid receptor (CB(1) R),...
9.
Gupta A, Mulder J, Gomes I, Rozenfeld R, Bushlin I, Ong E, et al.
Sci Signal
. 2010 Jul;
3(131):ra54.
PMID: 20647592
The mu and delta types of opioid receptors form heteromers that exhibit pharmacological and functional properties distinct from those of homomeric receptors. To characterize these complexes in the brain, we...
10.
Rozenfeld R, Devi L
Trends Pharmacol Sci
. 2010 Jan;
31(3):124-30.
PMID: 20060175
G-protein-coupled receptors (GPCRs) are membrane proteins that convert extracellular information into intracellular signals. They are involved in many biological processes and therefore represent powerful targets to modulate physiological and pathological...