Ranganath Gopalakrishnan
Overview
Explore the profile of Ranganath Gopalakrishnan including associated specialties, affiliations and a list of published articles.
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13
Citations
278
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Recent Articles
1.
Sampson J, Cannon D, Duan J, Epstein J, Sergeeva A, Katsamba P, et al.
J Mol Biol
. 2024 Jun;
436(16):168640.
PMID: 38844044
Computational free energy-based methods have the potential to significantly improve throughput and decrease costs of protein design efforts. Such methods must reach a high level of reliability, accuracy, and automation...
2.
Sampson J, Cannon D, Duan J, Epstein J, Sergeeva A, Katsamba P, et al.
bioRxiv
. 2024 May;
PMID: 38712280
Computational free energy-based methods have the potential to significantly improve throughput and decrease costs of protein design efforts. Such methods must reach a high level of reliability, accuracy, and automation...
3.
Bonciolini S, Pulcinella A, Leone M, Schiroli D, Ruiz A, Sorato A, et al.
Nat Commun
. 2024 Feb;
15(1):1509.
PMID: 38374079
In contemporary drug discovery, enhancing the sp-hybridized character of molecular structures is paramount, necessitating innovative synthetic methods. Herein, we introduce a deoxygenative cross-electrophile coupling technique that pairs easily accessible carboxylic...
4.
Noisier A, Gopalakrishnan R
Methods Mol Biol
. 2021 Aug;
2355:35-48.
PMID: 34386948
Synthetic molecular probes have recently been in focus for their potential use in target deconvolution, target engagement studies, and imaging. With the field expanding, new strategies to develop such tools...
5.
Adihou H, Gopalakrishnan R, Forster T, Gueret S, Gasper R, Geschwindner S, et al.
Nat Commun
. 2020 Oct;
11(1):5425.
PMID: 33110077
Transcription factors are key protein effectors in the regulation of gene transcription, and in many cases their activity is regulated via a complex network of protein-protein interactions (PPI). The chemical...
6.
Noisier A, Johansson M, Knerr L, Hayes M, Drury 3rd W, Valeur E, et al.
Angew Chem Int Ed Engl
. 2019 Oct;
58(52):19096-19102.
PMID: 31609503
The late-stage functionalization (LSF) of peptides represents a valuable strategy for the design of potent peptide pharmaceuticals by enabling rapid exploration of chemical diversity and offering novel opportunities for peptide...
7.
Valeur E, Gueret S, Adihou H, Gopalakrishnan R, Lemurell M, Waldmann H, et al.
Angew Chem Int Ed Engl
. 2017 Feb;
56(35):10294-10323.
PMID: 28186380
Our ever-increasing understanding of biological systems is providing a range of exciting novel biological targets, whose modulation may enable novel therapeutic options for many diseases. These targets include protein-protein and...
8.
Gopalakrishnan R, Frolov A, Knerr L, Drury 3rd W, Valeur E
J Med Chem
. 2016 Jul;
59(21):9599-9621.
PMID: 27362955
Over the past decade, foldamers have progressively emerged as useful architectures to mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid based backbones, have been the most...
9.
Kirmeier T, Gopalakrishnan R, Gormanns V, Werner A, Cuboni S, Rudolf G, et al.
PLoS One
. 2016 Feb;
11(2):e0148608.
PMID: 26863431
The aim of this study was to design, synthesize and validate a multifunctional antidepressant probe that is modified at two distinct positions. The purpose of these modifications was to allow...
10.
Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides
Chen S, Gopalakrishnan R, Schaer T, Marger F, Hovius R, Bertrand D, et al.
Nat Chem
. 2014 Oct;
6(11):1009-16.
PMID: 25343607
The disulfide bonds that form between two cysteine residues are important in defining and rigidifying the structures of proteins and peptides. In polypeptides containing multiple cysteine residues, disulfide isomerization can...