Andreas Bracher
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Explore the profile of Andreas Bracher including associated specialties, affiliations and a list of published articles.
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86
Citations
5470
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Recent Articles
1.
Zinzula L, Beck F, Camasta M, Bohn S, Liu C, Morado D, et al.
Nat Commun
. 2024 Nov;
15(1):10307.
PMID: 39604358
Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) complex structure in...
2.
Kamps J, Yuste-Checa P, Mamashli F, Schmitz M, Herrera M, da Silva Correia S, et al.
J Mol Biol
. 2024 Oct;
436(23):168839.
PMID: 39476948
Several proteins associated with neurodegenerative diseases, such as the mammalian prion protein (PrP), undergo liquid-liquid phase separation (LLPS), which led to the hypothesis that condensates represent precursors in the formation...
3.
Wagner J, Carvajal A, Bracher A, Beck F, Wan W, Bohn S, et al.
Nature
. 2024 Aug;
633(8029):459-464.
PMID: 39169181
Chaperonins are large barrel-shaped complexes that mediate ATP-dependent protein folding. The bacterial chaperonin GroEL forms juxtaposed rings that bind unfolded protein and the lid-shaped cofactor GroES at their apertures. In...
4.
Cairo L, Hong X, Muller M, Yuste-Checa P, Jagadeesan C, Bracher A, et al.
Cell
. 2024 Jun;
187(17):4656-4673.e28.
PMID: 38942013
The ability of proteins and RNA to coalesce into phase-separated assemblies, such as the nucleolus and stress granules, is a basic principle in organizing membraneless cellular compartments. While the constituents...
5.
Schafer S, Voll A, Bracher A, Ley S, Hausch F
Bioorg Med Chem Lett
. 2024 Apr;
104:129728.
PMID: 38582133
Antascomicin B is a natural product that similarly to the macrolides FK506 and Rapamycin binds to the FK506-binding protein 12 (FKBP12). FK506 and Rapamycin act as molecular glues by inducing...
6.
Bracher A, Verghese J
Subcell Biochem
. 2022 Dec;
101:1-39.
PMID: 36520302
Molecular chaperones of the Hsp70 family are key components of the cellular protein-folding machinery. Substrate folding is accomplished by iterative cycles of ATP binding, hydrolysis, and release. The ATPase activity...
7.
Zinzula L, Mereu A, Orsini M, Seeleitner C, Bracher A, Nagy I, et al.
iScience
. 2022 Nov;
25(11):105354.
PMID: 36325051
Ebola virus (EBOV) and Marburg virus (MARV) are highly pathogenic viruses in humans, against which approved antivirals are lacking. During EBOV and MARV infection, coiled-coil mediated oligomerization is essential for...
8.
Yuste-Checa P, Bracher A, Hartl F
Bioessays
. 2022 May;
44(7):e2100287.
PMID: 35521968
Fibrillar protein aggregates are the pathological hallmark of a group of age-dependent neurodegenerative conditions, including Alzheimer's and Parkinson's disease. Aggregates of the microtubule-associated protein Tau are observed in Alzheimer's disease...
9.
Kolos J, Pomplun S, Jung S, Riess B, Purder P, Voll A, et al.
Chem Sci
. 2021 Nov;
12(44):14758-14765.
PMID: 34820091
Methyl groups can have profound effects in drug discovery but the underlying mechanisms are diverse and incompletely understood. Here we report the stereospecific effect of a single, solvent-exposed methyl group...
10.
Schneider M, Gautam S, Herling T, Andrzejewska E, Krainer G, Miller A, et al.
Nat Commun
. 2021 Oct;
12(1):5999.
PMID: 34650037
Molecular chaperones contribute to the maintenance of cellular protein homoeostasis through assisting de novo protein folding and preventing amyloid formation. Chaperones of the Hsp70 family can further disaggregate otherwise irreversible...