Helene Adihou
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Explore the profile of Helene Adihou including associated specialties, affiliations and a list of published articles.
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17
Citations
288
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Recent Articles
1.
Sampson J, Cannon D, Duan J, Epstein J, Sergeeva A, Katsamba P, et al.
J Mol Biol
. 2024 Jun;
436(16):168640.
PMID: 38844044
Computational free energy-based methods have the potential to significantly improve throughput and decrease costs of protein design efforts. Such methods must reach a high level of reliability, accuracy, and automation...
2.
Sampson J, Cannon D, Duan J, Epstein J, Sergeeva A, Katsamba P, et al.
bioRxiv
. 2024 May;
PMID: 38712280
Computational free energy-based methods have the potential to significantly improve throughput and decrease costs of protein design efforts. Such methods must reach a high level of reliability, accuracy, and automation...
3.
Krzyzanowski A, Gasper R, Adihou H, t Hart P, Waldmann H
Chembiochem
. 2021 Feb;
22(11):1908-1914.
PMID: 33624332
The PRMT5-MEP50 methyltransferase complex plays a key role in various cancers and is regulated by different protein-protein interactions. Several proteins have been reported to act as adaptor proteins that recruit...
4.
Adihou H, Gopalakrishnan R, Forster T, Gueret S, Gasper R, Geschwindner S, et al.
Nat Commun
. 2020 Oct;
11(1):5425.
PMID: 33110077
Transcription factors are key protein effectors in the regulation of gene transcription, and in many cases their activity is regulated via a complex network of protein-protein interactions (PPI). The chemical...
5.
t Hart P, Hommen P, Noisier A, Krzyzanowski A, Schuler D, Porfetye A, et al.
Angew Chem Int Ed Engl
. 2020 Oct;
60(4):1813-1820.
PMID: 33022847
The scaffolding protein RbAp48 is part of several epigenetic regulation complexes and is overexpressed in a variety of cancers. In order to develop tool compounds for the study of RbAp48...
6.
Karatas H, Akbarzadeh M, Adihou H, Hahne G, Pobbati A, Ng E, et al.
J Med Chem
. 2020 Sep;
63(20):11972-11989.
PMID: 32907324
Transcriptional enhanced associate domain (TEAD) transcription factors together with coactivators and corepressors modulate the expression of genes that regulate fundamental processes, such as organogenesis and cell growth, and elevated TEAD...
7.
TEAD-YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics
Kunig V, Potowski M, Akbarzadeh M, Skopic M, Dos Santos Smith D, Arendt L, et al.
Angew Chem Int Ed Engl
. 2020 Jun;
59(46):20338-20342.
PMID: 32537835
DNA-encoded combinatorial synthesis provides efficient and dense coverage of chemical space around privileged molecular structures. The indole side chain of tryptophan plays a prominent role in key, or "hot spot",...
8.
Cromm P, Adihou H, Kapoor S, Vazquez-Chantada M, Davey P, Longmire D, et al.
Chembiochem
. 2019 Nov;
20(24):2987-2990.
PMID: 31680402
The acyl-binding UNC119 proteins mediate the activation and transport of various N-myristoylated proteins. In particular, UNC119a plays a crucial role in the completion of cytokinesis. Herein, we report the use...
9.
Zhou Q, Brauer A, Adihou H, Schmalhofer M, Saura P, Grammbitter G, et al.
Chem Sci
. 2019 Jul;
10(25):6341-6349.
PMID: 31341589
Anthraquinones, a widely distributed class of aromatic natural products, are produced by a type II polyketide synthase system in the Gram-negative bacterium . Heterologous expression of the anthraquinone biosynthetic gene...
10.
Wesche F, Adihou H, Wichelhaus T, Bode H
Beilstein J Org Chem
. 2019 Mar;
15:535-541.
PMID: 30873237
The repeated and improper use of antibiotics had led to an increased number of multiresistant bacteria. Therefore, new lead structures are needed. Here, the synthesis and an expanded structure-activity relationship...