Randall S Frey
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Explore the profile of Randall S Frey including associated specialties, affiliations and a list of published articles.
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16
Citations
932
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Recent Articles
1.
Karpurapu M, Wang X, Deng J, Park H, Xiao L, Sadikot R, et al.
Blood
. 2011 Sep;
118(19):5255-66.
PMID: 21937699
Although the role of ETS family transcriptional factor PU.1 is well established in macrophage maturation, its role in mature macrophages with reference to sepsis- related animal model has not been...
2.
Mirza M, Sun Y, Zhao Y, Potula H, Frey R, Vogel S, et al.
J Exp Med
. 2010 Jul;
207(8):1675-85.
PMID: 20660612
Repair of the injured vascular intima requires a series of coordinated events that mediate both endothelial regeneration and reannealing of adherens junctions (AJs) to form a restrictive endothelial barrier. The...
3.
Frey R, Ushio-Fukai M, Malik A
Antioxid Redox Signal
. 2008 Sep;
11(4):791-810.
PMID: 18783313
Reactive oxygen species (ROS) including superoxide (O(2)(.-)) and hydrogen peroxide (H(2)O(2)) are produced endogenously in response to cytokines, growth factors; G-protein coupled receptors, and shear stress in endothelial cells (ECs)....
4.
Bachmaier K, Toya S, Gao X, Triantafillou T, Garrean S, Park G, et al.
Nat Med
. 2007 Jul;
13(8):920-6.
PMID: 17618294
The E3 ubiquitin ligase Cblb has a crucial role in the prevention of chronic inflammation and autoimmunity. Here we show that Cblb also has an unexpected function in acute lung...
5.
Gao X, Zhu X, Fu J, Liu Q, Frey R, Malik A
J Biol Chem
. 2007 Jan;
282(9):6116-25.
PMID: 17197441
We examined the role of class IA phosphoinositide 3-kinase (PI3K) in the regulation of activation of NADPH oxidase in PMNs and the mechanism of PMN-dependent lung inflammation and microvessel injury...
6.
Zhao Y, Gao X, Zhao Y, Mirza M, Frey R, Kalinichenko V, et al.
J Clin Invest
. 2006 Sep;
116(9):2333-43.
PMID: 16955137
Recovery of endothelial integrity after vascular injury is vital for endothelial barrier function and vascular homeostasis. However, little is known about the molecular mechanisms of endothelial barrier repair following injury....
7.
Frey R, Gao X, Javaid K, Siddiqui S, Rahman A, Malik A
J Biol Chem
. 2006 Mar;
281(23):16128-38.
PMID: 16527821
We addressed the role of class 1B phosphatidylinositol 3-kinase (PI3K) isoform PI3Kgamma in mediating NADPH oxidase activation and reactive oxidant species (ROS) generation in endothelial cells (ECs) and of PI3Kgamma-mediated...
8.
Gao X, Liu Q, Broman M, Predescu D, Frey R, Malik A
Physiol Genomics
. 2005 Apr;
21(2):230-42.
PMID: 15831844
To inactivate chronically the beta2-integrin CD11b (Mac-1), we made a transgenic model in mice in which we expressed the CD11b antagonist polypeptide neutrophil inhibitory factor (NIF). Using these mice, we...
9.
Zhou X, Gao X, Fan J, Liu Q, Anwar K, Frey R, et al.
Am J Physiol Lung Cell Mol Physiol
. 2004 Nov;
288(4):L655-62.
PMID: 15563689
We identify herein a novel signaling function of the Toll-like receptor-4 (TLR4), the lipopolysaccharide (LPS) receptor mediating the innate immune response, in inducing the expression of CD11b/CD18 integrin in polymorphonuclear...
10.
Wang Y, Keogh R, Hunter M, Mitchell C, Frey R, Javaid K, et al.
J Immunol
. 2004 Nov;
173(11):6820-30.
PMID: 15557176
The Src homology 2-containing inositol phosphatase SHIP1 functions in hemopoietic cells to limit activation events mediated by PI3K products, including Akt activation and cell survival. In contrast to the limited...