Ramsay J McFarlane
Overview
Explore the profile of Ramsay J McFarlane including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
528
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Recent Articles
1.
Gomez-Escobar N, Alsaiari A, Alahamadi H, Alzahrani O, Vernon E, Althagafi H, et al.
PLoS Genet
. 2022 Jun;
18(6):e1010267.
PMID: 35714159
The conserved nucleic acid binding protein Translin contributes to numerous facets of mammalian biology and genetic diseases. It was first identified as a binder of cancer-associated chromosomal translocation breakpoint junctions...
2.
Krappinger J, Bonstingl L, Pansy K, Sallinger K, Wreglesworth N, Grinninger L, et al.
J Biotechnol
. 2021 Aug;
340:75-101.
PMID: 34371054
Non-coding natural antisense transcripts (ncNATs) are regulatory RNA molecules that are overlapping with as well as complementary to other transcripts. These transcripts are implicated in a broad variety of biological...
3.
McFarlane R, Wakeman J
Trends Cancer
. 2020 May;
6(6):450-453.
PMID: 32460000
Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point....
4.
Robinson H, McFarlane R, Wakeman J
Trends Cancer
. 2020 Mar;
6(4):271-273.
PMID: 32209441
New approaches to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecules. Brachyury is emerging as an exciting new drug target for the rare bone cancer chordoma. Here,...
5.
McFarlane R, Wakeman J
Cancer Res
. 2017 Oct;
77(21):5712-5716.
PMID: 29061671
Cancer cells have many abnormal characteristics enabling tumors to grow, spread, and avoid immunologic and therapeutic destruction. Central to this is the innate ability of populations of cancer cells to...
6.
Planells-Palop V, Hazazi A, Feichtinger J, Jezkova J, Thallinger G, Alsiwiehri N, et al.
Mol Cancer
. 2017 Apr;
16(1):84.
PMID: 28446200
Background: Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emerge to...
7.
Gomez-Escobar N, Almobadel N, Alzahrani O, Feichtinger J, Planells-Palop V, Alshehri Z, et al.
Oncotarget
. 2016 May;
7(23):33809-20.
PMID: 27183912
Translin and Trax proteins are highly conserved nucleic acid binding proteins that have been implicated in RNA regulation in a range of biological processes including tRNA processing, RNA interference, microRNA...
8.
Jezkova J, Williams J, Pinto F, Sammut S, Williams G, Gollins S, et al.
Oncotarget
. 2016 Feb;
7(10):11478-86.
PMID: 26862851
Normal homeostasis of adult intestinal epithelium and repair following tissue damage is maintained by a balance of stem and differentiated cells, many of which are still only poorly characterised. Enteroendocrine...
9.
McFarlane R, Feichtinger J, Larcombe L
Cell Cycle
. 2015 Mar;
14(6):791-2.
PMID: 25790090
No abstract available.
10.
A novel cohort of cancer-testis biomarker genes revealed through meta-analysis of clinical data sets
Sammut S, Feichtinger J, Stuart N, Wakeman J, Larcombe L, McFarlane R
Oncoscience
. 2015 Jan;
1(5):349-359.
PMID: 25594029
The identification of cancer-specific biomolecules is of fundamental importance to the development of diagnostic and/or prognostic markers, which may also serve as therapeutic targets. Some antigenic proteins are only normally...