Ramon Alajarin
Overview
Explore the profile of Ramon Alajarin including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
49
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0
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Recent Articles
1.
Martinez-Arias L, Fernandez-Villabrille S, Alonso-Montes C, Garcia-Navazo G, Ruiz-Torres M, Alajarin R, et al.
Nutrients
. 2023 Apr;
15(8).
PMID: 37111038
Drugs providing antihypertensive and protective cardiovascular actions are of clinical interest in controlling cardiovascular events and slowing the progression of kidney disease. We studied the effect of a hybrid compound,...
2.
Garcia-Marin J, Griera-Merino M, Matamoros-Recio A, de Frutos S, Rodriguez-Puyol M, Alajarin R, et al.
ACS Med Chem Lett
. 2021 Nov;
12(11):1656-1662.
PMID: 34790291
Integrin-linked kinase (ILK) has emerged as a controversial pseudokinase protein that plays a crucial role in the signaling process initiated by integrin-mediated signaling. However, ILK also exhibits a scaffolding protein...
3.
de Lucio H, Garcia-Marin J, Sanchez-Alonso P, Garcia-Soriano J, Toro M, Vaquero J, et al.
Eur J Med Chem
. 2021 Oct;
227:113915.
PMID: 34695777
Fifteen pyridazino-pyrrolo-quinoxalinium salts were synthesized and tested for their antiprotozoal activity against Leishmania infantum amastigotes. Eleven of them turned out to be leishmanicidal, with EC values in the nanomolar range,...
4.
Sanchez-Alonso P, Griera M, Garcia-Marin J, Rodriguez-Puyol M, Alajarin R, Vaquero J, et al.
Bioorg Med Chem
. 2021 Jul;
44:116295.
PMID: 34246920
Protein tyrosine phosphatase (PTP1B) is an interesting therapeutical target for diabetes, obesity, heart disease and cancer. As such, inhibition of PTP1B using orally administered drugs is still being pursued by...
5.
Garcia-Marin J, Griera M, Alajarin R, Rodriguez-Puyol M, Rodriguez-Puyol D, Vaquero J
ChemMedChem
. 2021 Jun;
16(18):2895-2906.
PMID: 34137509
Protein tyrosine phosphatase 1B (PTP1B) is a very promising target for the treatment of metabolic disorders such as type II diabetes mellitus. Although it was validated as a promising target...
6.
Garcia-Marin J, Griera M, Sanchez-Alonso P, Di Geronimo B, Mendicuti F, Rodriguez-Puyol M, et al.
ChemMedChem
. 2020 Sep;
15(19):1788-1801.
PMID: 32909701
PTP1B dephosphorylates insulin receptor and substrates to modulate glucose metabolism. This enzyme is a validated therapeutic target for type 2 diabetes, but no current drug candidates have completed clinical trials....
7.
Nieto E, Delgado M, Sobrado M, de Ceballos M, Alajarin R, Garcia-Garcia L, et al.
Eur J Med Chem
. 2015 Jul;
101:604-15.
PMID: 26204508
The synthesis of the new radiotracer precursor 4-Br-NITTP and the radiolabeling of the new tracer 1-(4-bromo-2-nitroimidazol-1-yl)-3-[(18)F]fluoropropan-2-ol (4-Br-[(18)F]FMISO) is reported. The cyclic voltammetry behaviour, neuronal cell toxicity, transport through the brain...
8.
Rodriguez-Sanz A, Sanchez-Alonso P, Bellon T, Alajarin R, Martinez-Cabeza V, Selgas R, et al.
Eur J Med Chem
. 2015 Feb;
93:83-92.
PMID: 25659754
Condensed polycyclic heteroaromatic cations bearing a bridgehead nitrogen with pyridazino[1',6':1,2]pyrido[3,4-b]indolinium and pyridazino[1,6-a]benzimidazolium structures were assayed as inhibitors of LPS-induced TNF-α production by THP-1 cells. The hit compound 1e, which had...
9.
Garcia G, Abet V, Alajarin R, Alvarez-Builla J, Delgado M, Garcia-Garcia L, et al.
Eur J Med Chem
. 2014 Aug;
85:795-806.
PMID: 25171752
N-(4-[(18)F]-Fluoropyridin-2-yl)-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-carboxamides were prepared by labeling their 4-nitropyridin-2-yl precursors through nitro substitution by the (18)F anion. In vitro and in vivo tests showed that the cyclohexanecarboxamide derivative is a reversible, selective...
10.
Gitto R, De Luca L, Ferro S, Russo E, De Sarro G, Chisari M, et al.
Bioorg Med Chem
. 2014 Jan;
22(3):1040-8.
PMID: 24411196
A three-step synthetic pathway has been employed to synthesize a small library of 2-(4-arylpiperidin-1-yl)-1-(1H-indol-3-yl)ethanone and 2-(4-arylpiperidin-1-yl)-1-(1H-indol-3-yl)ethane-1,2-dione derivatives that have been screened in [(3)H]ifenprodil competition binding assay. Some compounds exhibited significant...