Ramani Alla
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Explore the profile of Ramani Alla including associated specialties, affiliations and a list of published articles.
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11
Citations
398
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Recent Articles
1.
Kakraba S, Ayyadevara S, Penthala N, Balasubramaniam M, Ganne A, Liu L, et al.
Front Mol Neurosci
. 2020 Jan;
12:310.
PMID: 31920540
Age-progressive neurodegenerative pathologies, including Alzheimer's disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes protein aggregation, and is involved...
2.
Tarkhov A, Alla R, Ayyadevara S, Pyatnitskiy M, Menshikov L, Shmookler Reis R, et al.
Sci Rep
. 2019 May;
9(1):7368.
PMID: 31089188
We collected 60 age-dependent transcriptomes for C. elegans strains including four exceptionally long-lived mutants (mean adult lifespan extended 2.2- to 9.4-fold) and three examples of lifespan-increasing RNAi treatments. Principal Component...
3.
Ayyadevara S, Balasubramaniam M, Kakraba S, Alla R, Mehta J, Shmookler Reis R
Antioxid Redox Signal
. 2017 May;
27(17):1383-1396.
PMID: 28537433
Aims: Many progressive neurological disorders, including Alzheimer's disease (AD), Huntington's disease, and Parkinson's disease (PD), are characterized by accumulation of insoluble protein aggregates. In prospective trials, the cyclooxygenase inhibitor aspirin...
4.
Ayyadevara S, Balasubramaniam M, Parcon P, Barger S, Griffin W, Alla R, et al.
Aging Cell
. 2016 Jul;
15(5):924-39.
PMID: 27448508
Neurodegenerative diseases are distinguished by characteristic protein aggregates initiated by disease-specific 'seed' proteins; however, roles of other co-aggregated proteins remain largely unexplored. Compact hippocampal aggregates were purified from Alzheimer's and...
5.
Ayyadevara S, Balasubramaniam M, Johnson J, Alla R, Mackintosh S, Shmookler Reis R
Oncotarget
. 2016 Jul;
7(31):48870-48886.
PMID: 27429199
Class-I phosphatidylinositol 3-kinase (PI3KI) converts phosphatidylinositol 4,5-bisphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3). PIP3 comprises two fatty-acid chains that embed in lipid-bilayer membranes, joined by glycerol to inositol triphosphate. Proteins with...
6.
Ayyadevara S, Balasubramaniam M, Gao Y, Yu L, Alla R, Shmookler Reis R
Aging Cell
. 2014 Dec;
14(1):35-48.
PMID: 25510159
Age-dependent neurodegenerative diseases progressively form aggregates containing both shared components (e.g., TDP-43, phosphorylated tau) and proteins specific to each disease. We investigated whether diverse neuropathies might have additional aggregation-prone proteins...
7.
Ayyadevara S, Tazearslan C, Alla R, Jiang J, Jazwinski S, Shmookler Reis R
Front Genet
. 2014 Aug;
5:211.
PMID: 25136348
A quantitative trait locus (QTL) in the nematode C. elegans, "lsq4," was recently implicated by mapping longevity genes. QTLs for lifespan and three stress-resistance traits coincided within a span of...
8.
Bharill P, Ayyadevara S, Alla R, Shmookler Reis R
Front Genet
. 2013 Apr;
4:34.
PMID: 23543623
The regulation of animal longevity shows remarkable plasticity, in that a variety of genetic lesions are able to extend lifespan by as much as 10-fold. Such studies have implicated several...
9.
Shmookler Reis R, Xu L, Lee H, Chae M, Thaden J, Bharill P, et al.
Aging (Albany NY)
. 2011 Mar;
3(2):125-47.
PMID: 21386131
Many lifespan-modulating genes are involved in either generation of oxidative substrates and end-products, or their detoxification and removal. Among such metabolites, only lipoperoxides have the ability to produce free-radical chain...
10.
Ayyadevara S, Tazearslan C, Bharill P, Alla R, Siegel E, Shmookler Reis R
Aging Cell
. 2009 Sep;
8(6):706-25.
PMID: 19764929
Two age-1 nonsense mutants, truncating the class-I phosphatidylinositol 3-kinase catalytic subunit (PI3K(CS)) before its kinase domain, confer extraordinary longevity and stress-resistance to Caenorhabditis elegans. These traits, unique to second-generation homozygotes,...