Srinivas Ayyadevara
Overview
Explore the profile of Srinivas Ayyadevara including associated specialties, affiliations and a list of published articles.
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55
Citations
2245
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Recent Articles
1.
Pahal S, Mainali N, Balasubramaniam M, Shmookler Reis R, Ayyadevara S
Mitochondrion
. 2025 Mar;
82:102022.
PMID: 40023438
Mitochondria, essential for cellular energy, are crucial in neurodegenerative disorders (NDDs) and their age-related progression. This review highlights mitochondrial dynamics, mitovesicles, homeostasis, and organelle communication. We examine mitochondrial impacts from...
2.
Ganne A, Mainali N, Balasubramaniam M, Atluri R, Pahal S, Asante J, et al.
Aging Biol
. 2024 Sep;
2.
PMID: 39263528
Numerous factors predispose to progression of cognitive impairment to Alzheimer's disease and related dementias (ADRD), most notably age, (ε4) alleles, traumatic brain injury, heart disease, hypertension, obesity/diabetes, and Down's syndrome....
3.
Mazur A, Ayyadevara S, Mainali N, Patchett S, Uden M, Roa R, et al.
Cryobiology
. 2024 Mar;
115:104881.
PMID: 38437899
Cryoprotectant toxicity is a limiting factor for the cryopreservation of many living systems. We were moved to address this problem by the potential of organ vitrification to relieve the severe...
4.
Mainali N, Balasubramaniam M, Johnson J, Ayyadevara S, Shmookler Reis R
Bioinformation
. 2024 Feb;
20(1):4-10.
PMID: 38352912
Many age-progressive diseases are accompanied by (and likely caused by) the presence of protein aggregation in affected tissues. Protein aggregates are conjoined by complex protein-protein interactions, which remain poorly understood....
5.
Balasubramaniam M, Ganne A, Mainali N, Pahal S, Ayyadevara S, Shmookler Reis R
iScience
. 2024 Jan;
27(1):108745.
PMID: 38274404
Alzheimer's disease (AD) is characterized by peri-neuronal amyloid plaque and intra-neuronal neurofibrillary tangles. These aggregates are identified by the immunodetection of "seed" proteins (Aβ and hyperphosphorylated tau, respectively), but include...
6.
Balasubramaniam M, Narasimhappagari J, Liu L, Ganne A, Ayyadevara S, Atluri R, et al.
Commun Biol
. 2024 Jan;
7(1):60.
PMID: 38191671
Homozygosity for the ε4 allele of APOE increases the odds of developing Alzheimer's by 12 to 15 times relative to the most common ε3;ε3 genotype, and its association with higher...
7.
Mainali N, Li X, Wang X, Balasubramaniam M, Ganne A, Kore R, et al.
Mol Cell Biochem
. 2023 Nov;
479(10):2741-2753.
PMID: 37922111
Cardiovascular diseases, including myocardial infarction (MI), constitute the leading cause of morbidity and mortality worldwide. Protein-aggregate deposition is a hallmark of aging and neurodegeneration. Our previous study reported that aggregation...
8.
Kakraba S, Ayyadevara S, Mainali N, Balasubramaniam M, Bowroju S, Penthala N, et al.
Pharmaceuticals (Basel)
. 2023 Oct;
16(10).
PMID: 37895969
Chronic, low-grade inflammation has been implicated in aging and age-dependent conditions, including Alzheimer's disease, cardiomyopathy, and cancer. One of the age-associated processes underlying chronic inflammation is protein aggregation, which is...
9.
Kore R, Jenkins S, Jamshidi-Parsian A, Tackett A, Griffin R, Ayyadevara S, et al.
Biochem Biophys Rep
. 2023 May;
34:101463.
PMID: 37125076
Mesenchymal stem cell (MSC) exosomes have been found to attenuate cardiac systolic and diastolic dysfunction in animal models of ischemia. Exosomes carry a plethora of active and inactive proteins as...
10.
Mainali N, Ayyadevara S, Ganne A, Shmookler Reis R, Mehta J
J Cardiovasc Aging
. 2023 Apr;
3(2).
PMID: 37092014
Protein homeostasis, the balance between protein synthesis and degradation, requires the clearance of misfolded and aggregated proteins and is therefore considered to be an essential aspect of establishing a physiologically...