Ralph Haygood
Overview
Explore the profile of Ralph Haygood including associated specialties, affiliations and a list of published articles.
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21
Citations
891
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Recent Articles
1.
Berrio A, Haygood R, Wray G
BMC Genomics
. 2020 May;
21(1):359.
PMID: 32404186
Background: Adaptive changes in cis-regulatory elements are an essential component of evolution by natural selection. Identifying adaptive and functional noncoding DNA elements throughout the genome is therefore crucial for understanding...
2.
Babbitt C, Haygood R, Nielsen W, Wray G
BMC Genomics
. 2017 Jun;
18(1):435.
PMID: 28583075
Background: Despite evidence for adaptive changes in both gene expression and non-protein-coding, putatively regulatory regions of the genome during human evolution, the relationship between gene expression and adaptive changes in...
3.
Ives A, Paull C, Hulthen A, Downes S, Andow D, Haygood R, et al.
PLoS One
. 2017 Jan;
12(1):e0169167.
PMID: 28046073
Transgenic crops that express insecticide genes from Bacillus thuringiensis (Bt) are used worldwide against moth and beetle pests. Because these engineered plants can kill over 95% of susceptible larvae, they...
4.
Garfield D, Runcie D, Babbitt C, Haygood R, Nielsen W, Wray G
PLoS Biol
. 2013 Nov;
11(10):e1001696.
PMID: 24204211
Regulatory interactions buffer development against genetic and environmental perturbations, but adaptation requires phenotypes to change. We investigated the relationship between robustness and evolvability within the gene regulatory network underlying development...
5.
Garfield D, Haygood R, Nielsen W, Wray G
Evol Dev
. 2012 Sep;
14(2):152-67.
PMID: 23017024
Despite the fact that noncoding sequences comprise a substantial fraction of functional sites within all genomes, the evolutionary mechanisms that operate on genetic variation within regulatory elements remain poorly understood....
6.
Fedrigo O, Pfefferle A, Babbitt C, Haygood R, Wall C, Wray G
Brain Behav Evol
. 2011 Oct;
78(4):315-26.
PMID: 21986508
Differences in cognitive abilities and the relatively large brain are among the most striking differences between humans and their closest primate relatives. The energy trade-off hypothesis predicts that a major...
7.
Oliver T, Garfield D, Manier M, Haygood R, Wray G, Palumbi S
Genome Biol Evol
. 2010 Oct;
2:800-14.
PMID: 20935062
Comparisons of genomic sequence between divergent species can provide insight into the action of natural selection across many distinct classes of proteins. Here, we examine the extent of positive selection...
8.
Haygood R, Babbitt C, Fedrigo O, Wray G
Proc Natl Acad Sci U S A
. 2010 Apr;
107(17):7853-7.
PMID: 20385805
Changes in non-protein-coding regulatory DNA sequences have been proposed to play distinctive roles in adaptive evolution. We analyzed correlations between gene functions and evidence for positive selection in a common...
9.
Babbitt C, Silverman J, Haygood R, Reininga J, Rockman M, Wray G
Mol Biol Evol
. 2009 Nov;
27(2):465-79.
PMID: 19910384
Understanding genetic variation and its functional consequences within cis-regulatory regions remains an important challenge in human genetics and evolution. Here, we present a fine-scale functional analysis of segregating variation within...
10.
Warner L, Babbitt C, Primus A, Severson T, Haygood R, Wray G
Brain Res
. 2009 Jul;
1288:1-8.
PMID: 19591812
Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, is known to contain naturally occurring genetic variation in it's promoter region that associates with a number of neuropsychological disorders. As such,...