David Garfield
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Explore the profile of David Garfield including associated specialties, affiliations and a list of published articles.
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40
Citations
1124
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Recent Articles
1.
Lal A, Garfield D, Biancalani T, Eraslan G
Genome Res
. 2024 Sep;
34(9):1411-1420.
PMID: 39322281
-regulatory elements (CREs), such as promoters and enhancers, are DNA sequences that regulate the expression of genes. The activity of a CRE is influenced by the order, composition, and spacing...
2.
Sambandam A, Storm E, Tauc H, Hackney J, Garfield D, Caplazi P, et al.
Heliyon
. 2023 Mar;
9(3):e14238.
PMID: 36950615
The ability of stem cells to rapidly proliferate and differentiate is integral to the steady-state maintenance of tissues with high turnover such as the blood and intestine. Mutations that alter...
3.
McGarvey A, Kopp W, Vucicevic D, Mattonet K, Kempfer R, Hirsekorn A, et al.
Cell Genom
. 2023 Feb;
2(1):100083.
PMID: 36777038
DNA accessibility of -regulatory elements (CREs) dictates transcriptional activity and drives cell differentiation during development. While many genes regulating embryonic development have been identified, the underlying CRE dynamics controlling their...
4.
Yun J, Hansen S, Morris O, Madden D, Libeu C, Kumar A, et al.
Nat Commun
. 2023 Jan;
14(1):156.
PMID: 36631445
Cellular senescence and the senescence-associated secretory phenotype (SASP) are implicated in aging and age-related disease, and SASP-related inflammation is thought to contribute to tissue dysfunction in aging and diseased animals....
5.
Chang W, Matt A, Schewe M, Musinszki M, Grussel S, Brandenburg J, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(30).
PMID: 34301868
Otopetrins comprise a family of proton-selective channels that are critically important for the mineralization of otoliths and statoconia in vertebrates but whose underlying cellular mechanisms remain largely unknown. Here, we...
6.
Zhang S, Amourda C, Garfield D, Saunders T
Dev Cell
. 2018 Jul;
46(2):189-203.e4.
PMID: 30016621
The ability to form specific cell-cell connections within complex cellular environments is critical for multicellular organisms. However, the underlying mechanisms of cell matching that instruct these connections remain elusive. Here,...
7.
Hu Q, Li B, Garfield D, Ren S, Li A, Chen X, et al.
Thorac Cancer
. 2017 Sep;
3(2):162-168.
PMID: 28920299
Background: Lung cancer ranks as the top of cancer-related mortality in the world. Approximately 85-90% of all lung cancer cases are non-small cell lung cancer (NSCLC). For advanced NSCLC patients,...
8.
Cannavo E, Koelling N, Harnett D, Garfield D, Casale F, Ciglar L, et al.
Nature
. 2016 Dec;
541(7637):402-406.
PMID: 28024300
Embryonic development is driven by tightly regulated patterns of gene expression, despite extensive genetic variation among individuals. Studies of expression quantitative trait loci (eQTL) indicate that genetic variation frequently alters...
9.
Ahmadi N, Hajsadeghi F, Yehuda R, Anderson N, Garfield D, Ludmer C, et al.
Brain Inj
. 2015 Sep;
29(13-14):1635-41.
PMID: 26399477
Background: Traumatic-brain-injury (TBI) is a devastating-condition resulting in cerebral edema and ischemia. This study investigates the association of mild-TBI (mTBI) to sub-clinical atherosclerosis and cardiovascular (CV) mortality. Methods: Five hundred...
10.
Pan B, Wang R, Huang Y, Garfield D, Zhang J, Chen H
Onco Targets Ther
. 2015 Jun;
8:1185-91.
PMID: 26045672
Purpose: Although over-expression of hepatocyte growth factor (HGF) and neuregulin-1 (NRG1) are important mechanisms involved in acquired drug-resistance in many cancers, few reports have evaluated their clinicopathologic features and prognostic...