David A Garfield
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Explore the profile of David A Garfield including associated specialties, affiliations and a list of published articles.
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18
Citations
2264
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Recent Articles
1.
Cai X, Jia M, Heigl T, Shamir E, Wong A, Hall B, et al.
Cell Rep
. 2024 Aug;
43(8):114569.
PMID: 39088319
Wound healing in response to acute injury is mediated by the coordinated and transient activation of parenchymal, stromal, and immune cells that resolves to homeostasis. Environmental, genetic, and epigenetic factors...
2.
Flochlay S, Wong E, Zhao B, Viales R, Thomas-Chollier M, Thieffry D, et al.
Genome Res
. 2020 Dec;
31(2):211-224.
PMID: 33310749
Precise patterns of gene expression are driven by interactions between transcription factors, regulatory DNA sequences, and chromatin. How DNA mutations affecting any one of these regulatory "layers" are buffered or...
3.
Reddington J, Garfield D, Sigalova O, Calviello A, Marco-Ferreres R, Girardot C, et al.
Dev Cell
. 2020 Nov;
55(5):648-664.e9.
PMID: 33171098
Enhancers are essential drivers of cell states, yet the relationship between accessibility, regulatory activity, and in vivo lineage commitment during embryogenesis remains poorly understood. Here, we measure chromatin accessibility in...
4.
Peng P, Khoueiry P, Girardot C, Reddington J, Garfield D, Furlong E, et al.
Genome Biol Evol
. 2019 May;
11(7):1813-1828.
PMID: 31114856
Transcription factor (TF) binding is determined by sequence as well as chromatin accessibility. Although the role of accessibility in shaping TF-binding landscapes is well recorded, its role in evolutionary divergence...
5.
Cusanovich D, Reddington J, Garfield D, Daza R, Aghamirzaie D, Marco-Ferreres R, et al.
Nature
. 2018 Mar;
555(7697):538-542.
PMID: 29539636
Understanding how gene regulatory networks control the progressive restriction of cell fates is a long-standing challenge. Recent advances in measuring gene expression in single cells are providing new insights into...
6.
Schor I, Degner J, Harnett D, Cannavo E, Casale F, Shim H, et al.
Nat Genet
. 2017 Feb;
49(4):550-558.
PMID: 28191888
Animal promoters initiate transcription either at precise positions (narrow promoters) or dispersed regions (broad promoters), a distinction referred to as promoter shape. Although highly conserved, the functional properties of promoters...
7.
Runcie D, Dorey N, Garfield D, Stumpp M, Dupont S, Wray G
Genome Biol Evol
. 2017 Jan;
8(12):3672-3684.
PMID: 28082601
Ocean acidification (OA) is increasing due to anthropogenic CO2 emissions and poses a threat to marine species and communities worldwide. To better project the effects of acidification on organisms' health...
8.
Tica J, Lee E, Untergasser A, Meiers S, Garfield D, Gokcumen O, et al.
BMC Genomics
. 2016 May;
17:342.
PMID: 27161561
Background: While active LINE-1 (L1) elements possess the ability to mobilize flanking sequences to different genomic loci through a process termed transduction influencing genomic content and structure, an approach for...
9.
Cannavo E, Khoueiry P, Garfield D, Geeleher P, Zichner T, Gustafson E, et al.
Curr Biol
. 2015 Dec;
26(1):38-51.
PMID: 26687625
Embryogenesis is remarkably robust to segregating mutations and environmental variation; under a range of conditions, embryos of a given species develop into stereotypically patterned organisms. Such robustness is thought to...
10.
Hughes C, Foehr S, Garfield D, Furlong E, Steinmetz L, Krijgsveld J
Mol Syst Biol
. 2014 Nov;
10:757.
PMID: 25358341
In order to obtain a systems-level understanding of a complex biological system, detailed proteome information is essential. Despite great progress in proteomics technologies, thorough interrogation of the proteome from quantity-limited...