Rajkumar Noubade
Overview
Explore the profile of Rajkumar Noubade including associated specialties, affiliations and a list of published articles.
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31
Citations
1666
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Recent Articles
1.
Roy S, Fitzgerald K, Lalani A, Lai C, Kim A, Kim J, et al.
J Clin Invest
. 2023 Jun;
133(12).
PMID: 37317970
While the rapid advancement of immunotherapies has revolutionized cancer treatment, only a small fraction of patients derive clinical benefit. Eradication of large, established tumors appears to depend on engaging and...
2.
Belmontes B, Sawant D, Zhong W, Tan H, Kaul A, Aeffner F, et al.
Sci Transl Med
. 2021 Aug;
13(608).
PMID: 34433637
Therapeutic approaches are needed to promote T cell-mediated destruction of poorly immunogenic, "cold" tumors typically associated with minimal response to immune checkpoint blockade (ICB) therapy. Bispecific T cell engager (BiTE)...
3.
Lee H, Pham T, Chang M, Barnes D, Cai A, Noubade R, et al.
Cancer Res
. 2020 Jan;
80(8):1656-1668.
PMID: 31988076
The deubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with a high risk for mesothelioma and melanocytic tumors. Here, we show that pancreatic intraepithelial neoplasia driven by oncogenic...
4.
Noubade R, Majri-Morrison S, Tarbell K
Front Immunol
. 2019 May;
10:1014.
PMID: 31143179
Dendritic cells (DCs) efficiently process and present antigens to T cells, and by integrating environmental signals, link innate and adaptive immunity. DCs also control the balance between tolerance and immunity,...
5.
Arenzana T, Lianoglou S, Seki A, Eidenschenk C, Cheung T, Seshasayee D, et al.
Sci Immunol
. 2018 Apr;
3(22).
PMID: 29678836
Loss of function of the nuclear deubiquitinating enzyme BRCA1-associated protein-1 (BAP1) is associated with a wide spectrum of cancers. We report that tamoxifen-induced BAP1 deletion in adult mice resulted in...
6.
Wong K, Noubade R, Manzanillo P, Ota N, Foreman O, Hackney J, et al.
Nat Immunol
. 2017 May;
18(6):633-641.
PMID: 28459434
Microglia and other tissue-resident macrophages within the central nervous system (CNS) have essential roles in neural development, inflammation and homeostasis. However, the molecular pathways underlying their development and function remain...
7.
Baughman J, Rose C, Kolumam G, Webster J, Wilkerson E, Merrill A, et al.
Cell Rep
. 2016 Jul;
16(2):583-595.
PMID: 27373151
We introduce neutron-encoded (NeuCode) amino acid labeling of mice as a strategy for multiplexed proteomic analysis in vivo. Using NeuCode, we characterize an inducible knockout mouse model of Bap1, a...
8.
Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al.
Nature
. 2014 Dec;
518(7539):417-21.
PMID: 25470037
T-helper type 17 (TH17) cells that produce the cytokines interleukin-17A (IL-17A) and IL-17F are implicated in the pathogenesis of several autoimmune diseases. The differentiation of TH17 cells is regulated by...
9.
Noubade R, Wong K, Ota N, Rutz S, Eidenschenk C, Valdez P, et al.
Nature
. 2014 Apr;
509(7499):235-9.
PMID: 24739962
Reactive oxygen species (ROS) produced by phagocytes are essential for host defence against bacterial and fungal infections. Individuals with defective ROS production machinery develop chronic granulomatous disease. Conversely, excessive ROS...
10.
Murthy A, Li Y, Peng I, Reichelt M, Katakam A, Noubade R, et al.
Nature
. 2014 Feb;
506(7489):456-62.
PMID: 24553140
Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract. A single-nucleotide polymorphism (SNP) encoding a missense variant in the autophagy gene ATG16L1 (rs2241880,...