Rajesh Ravindran
Overview
Explore the profile of Rajesh Ravindran including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
2395
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0
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Recent Articles
1.
Kim E, Woodruff M, Grigoryan L, Maier B, Lee S, Mandal P, et al.
Elife
. 2020 Jun;
9.
PMID: 32515732
The squalene-based oil-in-water emulsion (SE) vaccine adjuvant MF59 has been administered to more than 100 million people in more than 30 countries, in both seasonal and pandemic influenza vaccines. Despite...
2.
Sinclair C, Bommakanti G, Gardinassi L, Loebbermann J, Johnson M, Hakimpour P, et al.
Science
. 2017 Aug;
357(6355):1014-1021.
PMID: 28798047
Antigen-presenting cells (APCs) occupy diverse anatomical tissues, but their tissue-restricted homeostasis remains poorly understood. Here, working with mouse models of inflammation, we found that mechanistic target of rapamycin (mTOR)-dependent metabolic...
3.
Ravindran R, Loebbermann J, Nakaya H, Khan N, Ma H, Gama L, et al.
Nature
. 2016 Mar;
531(7595):523-527.
PMID: 26982722
The integrated stress response (ISR) is a homeostatic mechanism by which eukaryotic cells sense and respond to stress-inducing signals, such as amino acid starvation. General controlled non-repressed (GCN2) kinase is...
4.
Godefroy E, Gallois A, Idoyaga J, Merad M, Tung N, Monu N, et al.
Cell Rep
. 2014 Dec;
9(5):1856-1870.
PMID: 25466255
Matrix metalloproteinase-2 (MMP-2) is involved in several physiological mechanisms, including wound healing and tumor progression. We show that MMP-2 directly stimulates dendritic cells (DCs) to both upregulate OX40L on the...
5.
Oh J, Ravindran R, Chassaing B, Carvalho F, Maddur M, Bower M, et al.
Immunity
. 2014 Sep;
41(3):478-492.
PMID: 25220212
Systems biological analysis of immunity to the trivalent inactivated influenza vaccine (TIV) in humans revealed a correlation between early expression of TLR5 and the magnitude of the antibody response. Vaccination...
6.
Bhowmick S, Ravindran R, Ali N
BMC Microbiol
. 2014 Jan;
14:8.
PMID: 24428931
Background: Visceral leishmaniasis caused by the protozoan parasite Leishmania donovani complex is a potentially fatal disease if left untreated. Few treatment options exist and are toxic, costly and ineffective against...
7.
Ravindran R, Khan N, Nakaya H, Li S, Loebbermann J, Maddur M, et al.
Science
. 2013 Dec;
343(6168):313-317.
PMID: 24310610
The yellow fever vaccine YF-17D is one of the most successful vaccines ever developed in humans. Despite its efficacy and widespread use in more than 600 million people, the mechanisms...
8.
Pulendran B, Oh J, Nakaya H, Ravindran R, Kazmin D
Immunol Rev
. 2013 Aug;
255(1):243-55.
PMID: 23947360
For more than a century, immunologists and vaccinologists have existed in parallel universes. Immunologists have for long reveled in using 'model antigens', such as chicken egg ovalbumin or nitrophenyl haptens,...
9.
Njau M, Kim J, Chappell C, Ravindran R, Thomas L, Pulendran B, et al.
J Immunol
. 2012 Aug;
189(6):2758-67.
PMID: 22908331
The interaction of CD28, which is constitutively expressed on T cells, with B7.1/B7.2 expressed on APCs is critical for T cell activation. CD28 is also expressed on murine and human...
10.
Ravindran R, Maji M, Ali N
Mol Pharm
. 2011 Dec;
9(1):59-70.
PMID: 22133194
The development of a long-term protective subunit vaccine against visceral leishmaniasis depends on antigens and adjuvants that can induce an appropriate immune response. The immunization of leishmanial antigens alone shows...