Rajesh K Kasam
Overview
Explore the profile of Rajesh K Kasam including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
254
Followers
0
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Recent Articles
1.
Johansen A, Kasam R, Vagnozzi R, Lin S, Gomez-Arroyo J, Shittu A, et al.
Circ Res
. 2024 Dec;
136(1):44-58.
PMID: 39629593
Background: TCF21 (transcription factor 21) is a bHLH (basic helix-loop-helix) protein required for the developmental specification of cardiac fibroblasts (CFs) from epicardial progenitor cells that surround the embryonic heart. In...
2.
Florens N, Kasam R, Rudman-Melnick V, Lin S, Prasad V, Molkentin J
Circulation
. 2023 Jan;
147(9):746-758.
PMID: 36695175
Background: Acute kidney injury (AKI) is a short-term life-threatening condition that, if survived, can lead to renal insufficiency and development of chronic kidney disease. The pathogenesis of AKI and chronic...
3.
Wessendarp M, Watanabe-Chailland M, Liu S, Stankiewicz T, Ma Y, Kasam R, et al.
Mitochondrion
. 2021 Nov;
62:85-101.
PMID: 34740864
Granulocyte-macrophage colony-stimulating factor (GM-CSF) exerts pleiotropic effects on macrophages and is required for self-renewal but the mechanisms responsible are unknown. Using mouse models with disrupted GM-CSF signaling, we show GM-CSF...
4.
Gajjala P, Kasam R, Soundararajan D, Sinner D, Huang S, Jegga A, et al.
JCI Insight
. 2021 Sep;
6(20).
PMID: 34520400
Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease associated with unremitting fibroblast activation including fibroblast-to-myofibroblast transformation (FMT), migration, resistance to apoptotic clearance, and excessive deposition of extracellular matrix...
5.
Vagnozzi R, Kasam R, Sargent M, Molkentin J
Circulation
. 2021 Jul;
144(4):328-331.
PMID: 34310160
No abstract available.
6.
Kasam R, Ghandikota S, Soundararajan D, Reddy G, Huang S, Jegga A, et al.
EMBO Mol Med
. 2020 Aug;
12(9):e12131.
PMID: 32761869
Fibroblast activation including proliferation, survival, and ECM production is central to initiation and maintenance of fibrotic lesions in idiopathic pulmonary fibrosis (IPF). However, druggable molecules that target fibroblast activation remain...
7.
Kasam R, Gajjala P, Jegga A, Courtney J, Randell S, Kramer E, et al.
J Cyst Fibros
. 2020 Jun;
19(5):815-822.
PMID: 32593509
Background: Cystic fibrosis (CF) patients develop severe lung disease including chronic airway infections, neutrophilic inflammation, and progressive fibrotic remodeling in airways. However, cellular and molecular processes that regulate excessive collagen...
8.
Kasam R, Reddy G, Jegga A, Madala S
Front Pharmacol
. 2019 Jun;
10:532.
PMID: 31156440
Impaired apoptotic clearance of myofibroblasts can result in the continuous expansion of scar tissue during the persistent injury in the lung. However, the molecular and cellular mechanisms underlying the apoptotic...
9.
Sontake V, Gajjala P, Kasam R, Madala S
Expert Opin Ther Targets
. 2018 Nov;
23(1):69-81.
PMID: 30468628
Fibrosis is an irreversible pathological endpoint in many chronic diseases, including pulmonary fibrosis. Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal condition characterized by (myo)fibroblast proliferation and transformation...
10.
Sontake V, Kasam R, Sinner D, Korfhagen T, Reddy G, White E, et al.
JCI Insight
. 2018 Aug;
3(16).
PMID: 30135315
Wilms' tumor 1 (WT1) is a critical transcriptional regulator of mesothelial cells during lung development but is downregulated in postnatal stages and adult lungs. We recently showed that WT1 is...