Rajendra N Mitra
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Explore the profile of Rajendra N Mitra including associated specialties, affiliations and a list of published articles.
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12
Citations
128
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Recent Articles
1.
Sp S, Mitra R, Zheng M, Chrispell J, Wang K, Kwon Y, et al.
Gene Ther
. 2023 Mar;
30(7-8):628-640.
PMID: 36935427
Gene therapy for autosomal dominant retinitis pigmentosa (adRP) is challenged by the dominant inheritance of the mutant genes, which would seemingly require a combination of mutant suppression and wild-type replacement...
2.
Zheng M, Mitra R, Weiss E, Han Z
Mol Ther
. 2019 Dec;
28(2):523-535.
PMID: 31879189
The use of gene therapy may allow replacement of the defective gene. Minigenes, such as cDNAs, are often used. However, these may not express normal physiological genetic profiles due to...
3.
Mitra R, Show K, Barman D, Sarkar S, Maiti D
J Org Chem
. 2018 Dec;
84(1):42-52.
PMID: 30562016
The N-heterocycle carbene (NHC)-catalyzed dual Stetter cascade reaction is discovered through coupling of β-nitrostyrene with phthalaldehyde under mild conditions to furnish valuable aryl-naphthoquinones. The generality of the new reaction is...
4.
Sarkar S, Laha R, Mitra R, Maiti D
ACS Omega
. 2018 Jul;
1(5):981-995.
PMID: 30023497
We assume formation of acyl-Pd--heterocyclic-carbene (NHC) organometalics for diverse C-O/O-C and C-C/C-O coupling catalysis of direct functionalization and cyclization reactions. We report the first use of dimethyl sulfoxide (DMSO) as...
5.
Asokan P, Mitra R, Periasamy R, Han Z, Borras T
Invest Ophthalmol Vis Sci
. 2018 Feb;
59(2):746-756.
PMID: 29392320
Purpose: Our goal was to generate and characterize a new mouse model in which only angiogenesis- and glaucoma-relevant tissues would be naturally fluorescent. The Matrix Gla (MGP) gene is highly...
6.
Mitra R, Gao R, Zheng M, Wu M, Voinov M, Smirnov A, et al.
ACS Nano
. 2017 May;
11(5):4669-4685.
PMID: 28463509
Age-related macular degeneration (AMD) is the foremost cause of irreversible blindness in people over the age of 65 especially in developing countries. Therefore, an exploration of effective and alternative therapeutic...
7.
Zheng M, Mitra R, Filonov N, Han Z
FASEB J
. 2015 Nov;
30(3):1076-86.
PMID: 26564956
Previously, we compared the efficacy of nanoparticle (NP)-mediated intron-containing rhodopsin (sgRho) vs. intronless cDNA in ameliorating retinal disease phenotypes in a rhodopsin knockout (RKO) mouse model of retinitis pigmentosa. We...
8.
Mitra R, Conley S, Naash M
Adv Exp Med Biol
. 2015 Oct;
854:463-9.
PMID: 26427447
Oxidative stress plays a role in many different forms of neurodegenerative ocular disease. The imbalance between the generation of endogenous reactive oxygen species (ROS) and their corresponding neutralization by endogenous...
9.
Mitra R, Merwin M, Han Z, Conley S, Al-Ubaidi M, Naash M
Free Radic Biol Med
. 2014 Jul;
75:140-8.
PMID: 25066531
Photoreceptor (PR) cells are prone to accumulation of reactive oxygen species (ROS) and oxidative stress. An imbalance between the production of ROS and cellular antioxidant defenses contributes to PR degeneration...
10.
Mitra R, Han Z, Merwin M, Al Taai M, Conley S, Naash M
ChemMedChem
. 2013 Nov;
9(1):189-96.
PMID: 24203490
Given the number of monogenic ocular diseases and the number of non-monogenic degenerative ocular diseases for which gene therapy is considered as a treatment, the development of effective therapeutic delivery...