Rainer E Martin
Overview
Explore the profile of Rainer E Martin including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
52
Citations
774
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Nippa D, Muller A, Atz K, Konrad D, Grether U, Martin R, et al.
Mol Inform
. 2025 Jan;
44(1):e202400361.
PMID: 39846425
Utilizing the growing wealth of chemical reaction data can boost synthesis planning and increase success rates. Yet, the effectiveness of machine learning tools for retrosynthesis planning and forward reaction prediction...
2.
Aebi J, Atz K, Ametamey S, Benz J, Blaising J, Butini S, et al.
Chimia (Aarau)
. 2024 Sep;
78(7-8):499-512.
PMID: 39221845
The endocannabinoid system (ECS) is a critical regulatory network composed of endogenous cannabinoids (eCBs), their synthesizing and degrading enzymes, and associated receptors. It is integral to maintaining homeostasis and orchestrating...
3.
Grether U, Foxton R, Gruener S, Korn C, Kimbara A, Osterwald A, et al.
Front Pharmacol
. 2024 Jul;
15:1426446.
PMID: 39070793
Introduction: Preclinical studies suggest that cannabinoid receptor type 2 (CB2R) activation has a therapeutic effect in animal models on chronic inflammation and vascular permeability, which are key pathological features of...
4.
Atz K, Nippa D, Muller A, Jost V, Anelli A, Reutlinger M, et al.
RSC Med Chem
. 2024 Jul;
15(7):2310-2321.
PMID: 39026644
Suzuki cross-coupling reactions are considered a valuable tool for constructing carbon-carbon bonds in small molecule drug discovery. However, the synthesis of chemical matter often represents a time-consuming and labour-intensive bottleneck....
5.
Gruber F, McDonagh A, Rose V, Hunter J, Guasch L, Martin R, et al.
Angew Chem Int Ed Engl
. 2024 Feb;
63(12):e202319836.
PMID: 38330151
DNA encoded library (DEL) synthesis represents a convenient means to produce, annotate and store large collections of compounds in a small volume. While DELs are well suited for drug discovery...
6.
Nippa D, Atz K, Hohler R, Muller A, Marx A, Bartelmus C, et al.
Nat Chem
. 2023 Nov;
16(2):239-248.
PMID: 37996732
Late-stage functionalization is an economical approach to optimize the properties of drug candidates. However, the chemical complexity of drug molecules often makes late-stage diversification challenging. To address this problem, a...
7.
Nippa D, Atz K, Muller A, Wolfard J, Isert C, Binder M, et al.
Commun Chem
. 2023 Nov;
6(1):256.
PMID: 37985850
Enhancing the properties of advanced drug candidates is aided by the direct incorporation of specific chemical groups, avoiding the need to construct the entire compound from the ground up. Nevertheless,...
8.
Reinhart A, Osterwald A, Ringler P, Leiser Y, Lauer M, Martin R, et al.
Mol Pharm
. 2023 Nov;
20(12):6492-6503.
PMID: 37975733
mRNA LNPs can experience a decline in activity over short periods (ranging from weeks to months). As a result, they require frozen storage and transportation conditions to maintain their full...
9.
Sela T, Manso M, Siegel M, Marban-Doran C, Ducret A, Niewohner J, et al.
Bioconjug Chem
. 2023 Nov;
34(11):2096-2111.
PMID: 37916986
Antisense-oligonucleotides (ASOs) are a promising drug modality for the treatment of neurological disorders, but the currently established route of administration intrathecal delivery is a major limitation to its broader clinical...
10.
Newton J, Engudar G, Brooke A, Nodwell M, Horngren-Rhodes H, Martin R, et al.
Chemistry
. 2022 Nov;
29(5):e202202862.
PMID: 36318597
The difluoromethyl group plays an important role in modern medicinal and agrochemistry. While several difluoromethylation reagents have been reported, these typically rely on difluoromethyl carbenes or anions, or target specific...