Rainer E Martin
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Explore the profile of Rainer E Martin including associated specialties, affiliations and a list of published articles.
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52
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Recent Articles
11.
Jepsen S, Wewer Albrechtsen N, Windelov J, Galsgaard K, Hunt J, Farb T, et al.
JCI Insight
. 2021 Jan;
6(4).
PMID: 33434183
Somatostatin (SS) inhibits glucagon-like peptide-1 (GLP-1) secretion in a paracrine manner. We hypothesized that blocking somatostatin subtype receptor 2 (SSTR2) and 5 (SSTR5) would improve glycemia by enhancing GLP-1 secretion....
12.
Newton J, Jelier B, Meanwell M, Martin R, Britton R, Friesen C
Org Lett
. 2020 Feb;
22(5):1785-1790.
PMID: 32053386
The reaction of nucleophilic tertiary amines with trifluoromethyl and pentafluoroethyl methyl ethers provides quaternary ammonium trifluoromethoxide (NROCF) and pentafluoroethoxide (NROCFCF) salts, respectively, in good yields. The new trifluoromethoxide salts disclosed...
13.
Newton J, Driedger D, Nodwell M, Schaffer P, Martin R, Britton R, et al.
Chemistry
. 2019 Sep;
25(70):15993-15997.
PMID: 31538366
Herein we report the mild and rapid fluorodesulfurization of thionoesters using only silver(I) fluoride. This reaction demonstrates excellent functional group tolerance and complements existing strategies for difluoroalkyl ether synthesis, which...
14.
Jepsen S, Grunddal K, Wewer Albrechtsen N, Engelstoft M, Gabe M, Jensen E, et al.
Am J Physiol Endocrinol Metab
. 2019 Sep;
317(6):E1081-E1093.
PMID: 31503512
DPP-4 inhibitors, used for treatment of type 2 diabetes, act by increasing the concentrations of intact glucagon-like peptide-1 (GLP-1), but at the same time, they inhibit secretion of GLP-1, perhaps...
15.
Schnider P, Dolente C, Stalder H, Martin R, Reinmuller V, Marty R, et al.
Chembiochem
. 2019 Sep;
21(1-2):212-234.
PMID: 31491045
Thirteen epimeric pairs of 5-substituted N-piperonyl-3-phenylpiperidine derivatives were synthesized in order to explore the stereospecific modulation of basicity, lipophilicity, aqueous solubility, and membrane permeation by functional groups in equatorial or...
16.
Nodwell M, Yang H, Merkens H, Malik N, Colovic M, Wagner B, et al.
J Nucl Med
. 2019 Jan;
60(7):1003-1009.
PMID: 30683769
The large, neutral L-type amino acid transporters (LAT1-LAT4) are sodium-independent transporters that are widely distributed throughout the body. LAT expression levels are increased in many types of cancer, and their...
17.
Meanwell M, Lehmann J, Eichenberger M, Martin R, Britton R
Chem Commun (Camb)
. 2018 Aug;
54(71):9985-9988.
PMID: 30123905
Acyl fluorides are versatile acylating agents owing to their unique stability. Their synthesis, however, can present challenges and is typically accomplished through deoxyfluorination of carboxylic acids. Here, we demonstrate that...
18.
Yuan Z, Nodwell M, Yang H, Malik N, Merkens H, Benard F, et al.
Angew Chem Int Ed Engl
. 2018 Aug;
57(39):12733-12736.
PMID: 30086209
Peptides are often ideal ligands for diagnostic molecular imaging due to their ease of synthesis and tuneable targeting properties. However, labelling unmodified peptides with F for positron emission tomography (PET)...
19.
Meanwell M, Adluri B, Yuan Z, Newton J, Prevost P, Nodwell M, et al.
Chem Sci
. 2018 Aug;
9(25):5608-5613.
PMID: 30061993
Functionalization of heterocyclic scaffolds with mono- or difluoroalkyl groups provides unique opportunities to modulate drug p, influence potency and membrane permeability, and attenuate metabolism. While advances in the addition of...
20.
Martin R, Mader T, Diederich F
Angew Chem Int Ed Engl
. 2018 May;
38(6):817-821.
PMID: 29711791
With 16 C-C double and 32 C-C triple bonds and a length of 11.9 nm, the hexadecameric poly(triacetylene) (PTA) of type 1 is currently the longest linear fully π-conjugated molecular...