Rafi Ahmed
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Explore the profile of Rafi Ahmed including associated specialties, affiliations and a list of published articles.
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402
Citations
44827
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Recent Articles
11.
Saba N, Wong S, Nasti T, McCook-Veal A, McDonald M, Stokes W, et al.
JAMA Oncol
. 2024 May;
10(7):896-904.
PMID: 38780927
Importance: Intensity-modulated radiation therapy (IMRT) reirradiation of nonmetastatic recurrent or second primary head and neck squamous cell carcinoma (HNSCC) results in poor progression-free survival (PFS) and overall survival (OS). Objective:...
12.
McManus D, Valanparambil R, Medina C, Hu Y, Scharer C, Sobierajska E, et al.
Res Sq
. 2024 Feb;
PMID: 38410458
Virus specific PD-1+ TCF-1+ TOX+ stem-like CD8+ T cells are essential for maintaining T cell responses during chronic infection and are also critical for PD-1 directed immunotherapy. In this study...
13.
van der Heide V, Davenport B, Cubitt B, Roudko V, Choo D, Humblin E, et al.
bioRxiv
. 2024 Feb;
PMID: 38328184
Generation of functional CD8 T cell memory typically requires engagement of CD4 T cells. However, in certain scenarios, such as acutely-resolving viral infections, effector (T ) and subsequent memory (T...
14.
Aggarwal C, Ahmed H, Sharma P, Reddy E, Nayak K, Singla M, et al.
Nat Med
. 2024 Feb;
30(3):670-674.
PMID: 38321219
Dengue is a global epidemic causing over 100 million cases annually. The clinical symptoms range from mild fever to severe hemorrhage and shock, including some fatalities. The current paradigm is...
15.
Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision
Abadie K, Clark E, Valanparambil R, Ukogu O, Yang W, Daza R, et al.
Immunity
. 2024 Feb;
57(2):271-286.e13.
PMID: 38301652
The immune system encodes information about the severity of a pathogenic threat in the quantity and type of memory cells it forms. This encoding emerges from lymphocyte decisions to maintain...
16.
Saphire E, Salie Z, Ke Z, Halfmann P, DeWald L, McArdle S, et al.
Res Sq
. 2024 Jan;
PMID: 38196595
Monoclonal antibodies (mAbs) against Ebola virus (EBOV) glycoprotein (GP) are the standard of care for Ebola virus disease (EVD). Anti-GP mAbs targeting the stalk and membrane proximal external region (MPER)...
17.
Hashimoto M, Ramalingam S, Ahmed R
Trends Cancer
. 2023 Dec;
10(4):332-346.
PMID: 38129234
There is considerable interest in developing more effective programmed cell death (PD)-1 combination therapies against cancer. One major obstacle to these efforts is a dysfunctional/exhausted state of CD8 T cells,...
18.
Chen C, Zheng H, Horwitz E, Ando S, Araki K, Zhao P, et al.
Sci Adv
. 2023 Dec;
9(49):eadf9522.
PMID: 38055827
Mitochondria use different substrates for energy production and intermediatory metabolism according to the availability of nutrients and oxygen levels. The role of mitochondrial metabolic flexibility for CD8 T cell immune...
19.
Mariniello A, Nasti T, Chang D, Hashimoto M, Malik S, McManus D, et al.
Clin Cancer Res
. 2023 Nov;
30(9):1833-1845.
PMID: 37992307
Purpose: Combination of chemotherapy with programmed cell death 1 (PD-1) blockade is a front-line treatment for lung cancer. However, it remains unknown whether and how chemotherapy affects the response of...
20.
Valanparambil R, Lai L, Johns M, Davis-Gardner M, Linderman S, McPherson T, et al.
NPJ Vaccines
. 2023 Nov;
8(1):179.
PMID: 37990024
This study reports that most patients with NSCLC had a significant increase in the nAb response to the currently circulating Omicron variants after bivalent booster vaccination and had Ab titers...