Raffael Nachbagauer
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Explore the profile of Raffael Nachbagauer including associated specialties, affiliations and a list of published articles.
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79
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3288
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Recent Articles
11.
Widge A, Hofstetter A, Houser K, Awan S, Chen G, Burgos Florez M, et al.
Sci Transl Med
. 2023 Apr;
15(692):eade4790.
PMID: 37075129
Influenza vaccines could be improved by platforms inducing cross-reactive immunity. Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines impedes induction of cross-reactive neutralizing stem-directed antibodies. A vaccine...
12.
Cable J, Graham B, Koup R, Seder R, Kariko K, Pardi N, et al.
Ann N Y Acad Sci
. 2023 Apr;
1524(1):65-86.
PMID: 37020354
The COVID-19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity...
13.
Alsoussi W, Malladi S, Zhou J, Liu Z, Ying B, Kim W, et al.
Nature
. 2023 Apr;
617(7961):592-598.
PMID: 37011668
The primary two-dose SARS-CoV-2 mRNA vaccine series are strongly immunogenic in humans, but the emergence of highly infectious variants necessitated additional doses and the development of vaccines aimed at the...
14.
Alsoussi W, Malladi S, Zhou J, Liu Z, Ying B, Kim W, et al.
bioRxiv
. 2022 Sep;
PMID: 36172127
The primary two-dose SARS-CoV-2 mRNA vaccine series are strongly immunogenic in humans, but the emergence of highly infectious variants necessitated additional doses of these vaccines and the development of new...
15.
Folschweiller N, Abeele C, Chu L, Van Damme P, Garcia-Sastre A, Krammer F, et al.
Lancet Infect Dis
. 2022 Apr;
22(7):1062-1075.
PMID: 35461522
Background: One strategy to develop a universal influenza virus vaccine is to redirect the immune system to the highly conserved haemagglutinin stalk domain by sequentially administering vaccines expressing chimeric (c)...
16.
Houser K, Chen G, Carter C, Crank M, Nguyen T, Burgos Florez M, et al.
Nat Med
. 2022 Feb;
28(2):383-391.
PMID: 35115706
Currently, licensed seasonal influenza vaccines display variable vaccine effectiveness, and there remains a need for novel vaccine platforms capable of inducing broader responses against viral protein domains conserved among influenza...
17.
Bliss C, Freyn A, Caniels T, Leyva-Grado V, Nachbagauer R, Sun W, et al.
Mol Ther
. 2022 Jan;
30(5):2024-2047.
PMID: 34999208
Conventional influenza vaccines fail to confer broad protection against diverse influenza A viruses with pandemic potential. Efforts to develop a universal influenza virus vaccine include refocusing immunity towards the highly...
18.
Guthmiller J, Han J, Utset H, Li L, Lan L, Henry C, et al.
Nature
. 2021 Dec;
602(7896):314-320.
PMID: 34942633
Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against influenza virus infection. However, viral mutants that escape broadly...
19.
Freyn A, Pine M, Rosado V, Benz M, Muramatsu H, Beattie M, et al.
Mol Ther Methods Clin Dev
. 2021 Sep;
22:84-95.
PMID: 34485597
Nucleoside-modified, lipid nanoparticle-encapsulated mRNAs have recently emerged as suitable vaccines for influenza viruses and other pathogens in part because the platform allows delivery of multiple antigens in a single immunization....
20.
Guthmiller J, Han J, Li L, Freyn A, Liu S, Stovicek O, et al.
Sci Transl Med
. 2021 Jun;
13(596).
PMID: 34078743
Broadly neutralizing antibodies are critical for protection against both drifted and shifted influenza viruses. Here, we reveal that first exposure to the 2009 pandemic H1N1 influenza virus recalls memory B...