Alec W Freyn
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Explore the profile of Alec W Freyn including associated specialties, affiliations and a list of published articles.
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19
Citations
698
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Recent Articles
1.
Cotter C, Ignacio M, Americo J, Earl P, Mucker E, Frey T, et al.
NPJ Vaccines
. 2024 Dec;
9(1):256.
PMID: 39719481
We previously reported that mice immunized twice with a lipid nanoparticle vaccine comprising four monkeypox viral mRNAs raised neutralizing antibodies and antigen-specific T cells and were protected against a lethal...
2.
Cotter C, Ignacio M, Americo J, Earl P, Mucker E, Hooper J, et al.
bioRxiv
. 2024 Oct;
PMID: 39372733
The increasing incidence of mpox in Africa and the recent global outbreak with evidence of sexual transmission have stimulated interest in new vaccines and therapeutics. Our previous study demonstrated that...
3.
Mucker E, Freyn A, Bixler S, Cizmeci D, Atyeo C, Earl P, et al.
Cell
. 2024 Sep;
187(20):5540-5553.e10.
PMID: 39236707
In 2022, mpox virus (MPXV) spread worldwide, causing 99,581 mpox cases in 121 countries. Modified vaccinia Ankara (MVA) vaccine use reduced disease in at-risk populations but failed to deliver complete...
4.
Freyn A, Atyeo C, Earl P, Americo J, Chuang G, Natarajan H, et al.
Sci Transl Med
. 2023 Oct;
15(716):eadg3540.
PMID: 37792954
Mpox virus (MPXV) caused a global outbreak in 2022. Although smallpox vaccines were rapidly deployed to curb spread and disease among those at highest risk, breakthrough disease was noted after...
5.
Widge A, Hofstetter A, Houser K, Awan S, Chen G, Burgos Florez M, et al.
Sci Transl Med
. 2023 Apr;
15(692):eade4790.
PMID: 37075129
Influenza vaccines could be improved by platforms inducing cross-reactive immunity. Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines impedes induction of cross-reactive neutralizing stem-directed antibodies. A vaccine...
6.
Houser K, Chen G, Carter C, Crank M, Nguyen T, Burgos Florez M, et al.
Nat Med
. 2022 Feb;
28(2):383-391.
PMID: 35115706
Currently, licensed seasonal influenza vaccines display variable vaccine effectiveness, and there remains a need for novel vaccine platforms capable of inducing broader responses against viral protein domains conserved among influenza...
7.
Bliss C, Freyn A, Caniels T, Leyva-Grado V, Nachbagauer R, Sun W, et al.
Mol Ther
. 2022 Jan;
30(5):2024-2047.
PMID: 34999208
Conventional influenza vaccines fail to confer broad protection against diverse influenza A viruses with pandemic potential. Efforts to develop a universal influenza virus vaccine include refocusing immunity towards the highly...
8.
Guthmiller J, Han J, Utset H, Li L, Lan L, Henry C, et al.
Nature
. 2021 Dec;
602(7896):314-320.
PMID: 34942633
Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against influenza virus infection. However, viral mutants that escape broadly...
9.
Maisonnasse P, Aldon Y, Marc A, Marlin R, Dereuddre-Bosquet N, Kuzmina N, et al.
Nat Commun
. 2021 Oct;
12(1):6097.
PMID: 34671037
Effective treatments against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising results in patients. Here, we evaluate the in vivo prophylactic and therapeutic...
10.
Freyn A, Pine M, Rosado V, Benz M, Muramatsu H, Beattie M, et al.
Mol Ther Methods Clin Dev
. 2021 Sep;
22:84-95.
PMID: 34485597
Nucleoside-modified, lipid nanoparticle-encapsulated mRNAs have recently emerged as suitable vaccines for influenza viruses and other pathogens in part because the platform allows delivery of multiple antigens in a single immunization....