Rafael Miguez Counago
Overview
Explore the profile of Rafael Miguez Counago including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
52
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Recent Articles
1.
Ghoshal A, Tse E, Hossain M, Asressu K, Merten E, Sears J, et al.
Res Sq
. 2024 Nov;
PMID: 39606462
RA-0003022 () was identified as a high-quality covalent chemical probe for nsP2 cysteine protease (nsP2pro). Isoxazole covalently captured the active site C478 and inactivated the enzyme with a / ratio...
2.
Merten E, Sears J, Leisner T, Hardy P, Ghoshal A, Hossain M, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(42):e2409166121.
PMID: 39388272
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has been responsible for numerous large-scale outbreaks in the last twenty years. Currently, there are no FDA-approved therapeutics for any alphavirus infection....
3.
Gontijo M, Pereira Teles M, Martins Correia H, Jorge G, Rodrigues Santos Goes I, Fasabi Flores A, et al.
Microbiology (Reading)
. 2024 May;
170(5).
PMID: 38739436
Endolysins are bacteriophage (or phage)-encoded enzymes that catalyse the peptidoglycan breakdown in the bacterial cell wall. The exogenous action of recombinant phage endolysins against Gram-positive organisms has been extensively studied....
4.
Marcelino T, Fala A, da Silva M, Souza-Melo N, Malvezzi A, Klippel A, et al.
J Biol Chem
. 2023 May;
299(7):104857.
PMID: 37230387
The TcK2 protein kinase of Trypanosoma cruzi, the causative agent of Chagas disease, is structurally similar to the human kinase PERK, which phosphorylates the initiation factor eIF2α and, in turn,...
5.
Fernandes Silva S, Klippel A, Zonzini Ramos P, Da Silva Santiago A, Valentini S, Bengtson M, et al.
PLoS Negl Trop Dis
. 2020 Oct;
14(10):e0008762.
PMID: 33044977
Deoxyhypusine synthase (DHS) catalyzes the first step of the post-translational modification of eukaryotic translation factor 5A (eIF5A), which is the only known protein containing the amino acid hypusine. Both proteins...
6.
Chang C, Counago R, Williams S, Boden M, Kobe B
Traffic
. 2016 May;
17(6):704.
PMID: 27174377
No abstract available.
7.
Chang C, Williams S, Counago R, Kobe B
Mol Plant
. 2014 Feb;
7(6):1061-1064.
PMID: 24503158
No abstract available.
8.
Chang C, Counago R, Williams S, Boden M, Kobe B
Plant Signal Behav
. 2013 Nov;
8(10).
PMID: 24270630
The specific recognition between the import receptor importin-α and the nuclear localization signals (NLSs) is crucial to ensure the selective transport of cargoes into the nucleus. NLSs contain 1 or...
9.
Chang C, Counago R, Williams S, Boden M, Kobe B
Traffic
. 2013 Aug;
14(11):1144-54.
PMID: 23910026
Nuclear localization signals (NLSs) contain one or two clusters of basic residues and are recognized by the import receptor importin-α. There are two NLS-binding sites (major and minor) on importin-α...
10.
Counago R, Fleming S, Mercer A, Krause K
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2010 Jul;
66(Pt 7):819-23.
PMID: 20606282
The parapoxvirus orf virus (ORFV) encodes a chemokine-binding protein (CBP) that functions to downregulate the host's immune response at the site of infection by blocking the chemokine-induced recruitment of immune...