Rafael Alcala-Vida
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Explore the profile of Rafael Alcala-Vida including associated specialties, affiliations and a list of published articles.
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14
Citations
143
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Recent Articles
1.
Brule B, Alcala-Vida R, Penaud N, Scuto J, Mounier C, Seguin J, et al.
Nat Commun
. 2025 Feb;
16(1):1550.
PMID: 39934111
Loss of epigenetic information during physiological aging compromises cellular identity, leading to de-repression of developmental genes. Here, we assessed the epigenomic landscape of vulnerable neurons in two reference mouse models...
2.
Alcala-Vida R, Barco A
Neuron
. 2024 Sep;
112(17):2829-2832.
PMID: 39236677
In this issue of Neuron, Torres-Berrío et al. show that stress-susceptible mice exhibit elevated H3K27me1 levels in nucleus accumbens neurons due to the action of the SUZ12 VEFS domain, strengthening...
3.
Paiva I, Seguin J, Grgurina I, Singh A, Cosquer B, Plassard D, et al.
Neurobiol Dis
. 2024 May;
198:106538.
PMID: 38789057
Aging is the main risk factor of cognitive neurodegenerative diseases such as Alzheimer's disease, with epigenome alterations as a contributing factor. Here, we compared transcriptomic/epigenomic changes in the hippocampus, modified...
4.
Tzeplaeff L, Seguin J, Le Gras S, Megat S, Cosquer B, Plassard D, et al.
Prog Neurobiol
. 2023 Jun;
227:102483.
PMID: 37327984
Cytoplasmic mislocalization of the nuclear Fused in Sarcoma (FUS) protein is associated to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS accumulation is recapitulated in the frontal cortex...
5.
Alcala-Vida R, Lotz C, Brule B, Seguin J, Decraene C, Awada A, et al.
Prog Neurobiol
. 2022 Sep;
219:102363.
PMID: 36179935
Molecular mechanisms underlying cognitive deficits in Huntington's disease (HD), a striatal neurodegenerative disorder, are unknown. Here, we generated ChIPseq, 4Cseq and RNAseq data on striatal tissue of HD and control...
6.
Pupak A, Singh A, Sancho-Balsells A, Alcala-Vida R, Espina M, Giralt A, et al.
Cell Mol Life Sci
. 2022 Jul;
79(8):416.
PMID: 35819730
N6-methyladenosine (m6A) regulates many aspects of RNA metabolism and is involved in learning and memory processes. Yet, the impact of a dysregulation of post-transcriptional m6A editing on synaptic impairments in...
7.
Hippocampal Cannabinoid 1 Receptors Are Modulated Following Cocaine Self-administration in Male Rats
De Sa Nogueira D, Bourdy R, Alcala-Vida R, Filliol D, Andry V, Goumon Y, et al.
Mol Neurobiol
. 2022 Jan;
59(3):1896-1911.
PMID: 35032317
Cocaine addiction is a complex pathology inducing long-term neuroplastic changes that, in turn, contribute to maladaptive behaviors. This behavioral dysregulation is associated with transcriptional reprogramming in brain reward circuitry, although...
8.
Alcala-Vida R, Seguin J, Lotz C, Molitor A, Irastorza-Azcarate I, Awada A, et al.
Nat Commun
. 2021 Jan;
12(1):364.
PMID: 33441541
Temporal dynamics and mechanisms underlying epigenetic changes in Huntington's disease (HD), a neurodegenerative disease primarily affecting the striatum, remain unclear. Using a slowly progressing knockin mouse model, we profile the...
9.
Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease
Alcala-Vida R, Garcia-Forn M, Castany-Pladevall C, Creus-Muncunill J, Ito Y, Blanco E, et al.
EMBO Mol Med
. 2020 Dec;
13(2):e12105.
PMID: 33369245
Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington's disease (HD), a CAG repeat-associated neurodegenerative...
10.
Alcala-Vida R, Awada A, Boutillier A, Merienne K
Neurobiol Dis
. 2020 Oct;
147:105155.
PMID: 33127472
Neurodegenerative diseases, including Huntington's disease (HD) and Alzheimer's disease (AD), are progressive conditions characterized by selective, disease-dependent loss of neuronal regions and/or subpopulations. Neuronal loss is preceded by a long...