Rafael Alcala-Torano
Overview
Explore the profile of Rafael Alcala-Torano including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
58
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0
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Recent Articles
1.
Alcala-Torano R, Islam M, Cika J, Lam K, Jin R, Ichtchenko K, et al.
ACS Chem Biol
. 2022 Dec;
17(12):3435-3449.
PMID: 36459441
While covalent drug discovery is reemerging as an important route to small-molecule therapeutic leads, strategies for the discovery and engineering of protein-based irreversible binding agents remain limited. Here, we describe...
2.
Alcala-Torano R, Halloran N, Gwerder N, Sommer D, Ghirlanda G
Front Mol Biosci
. 2021 May;
8:609654.
PMID: 33937320
The current trend in atmospheric carbon dioxide concentrations is causing increasing concerns for its environmental impacts, and spurring the developments of sustainable methods to reduce CO to usable molecules. We...
3.
Dong M, Harikumar K, Raval S, Milburn J, Clark C, Alcala-Torano R, et al.
Biochem Pharmacol
. 2020 Mar;
177:113929.
PMID: 32217097
The secretin receptor is a prototypic class B GPCR with substantial and broad pharmacologic importance. The aim of this project was to develop a high affinity selective antagonist as a...
4.
Alcala-Torano R, Walther M, Sommer D, Park C, Ghirlanda G
Biopolymers
. 2018 Sep;
109(10):e23233.
PMID: 30191549
Protein-based self-assembled nanostructures hold tremendous promise as smart materials. One strategy to control the assembly of individual protein modules takes advantage of the directionality and high affinity bonding afforded by...
5.
Sommer D, Alcala-Torano R, Bahrami Dizicheh Z, Ghirlanda G
Adv Exp Med Biol
. 2016 Sep;
940:215-243.
PMID: 27677515
In nature, the majority of processes that occur in the cell involve the cycling of electrons and protons, changing the reduction and oxidation state of substrates to alter their chemical...
6.
Maini R, Nguyen D, Chen S, Dedkova L, Roy Chowdhury S, Alcala-Torano R, et al.
Bioorg Med Chem
. 2013 Feb;
21(5):1088-96.
PMID: 23375097
Ribosomes containing modifications in three regions of 23S rRNA, all of which are in proximity to the ribosomal peptidyltransferase center (PTC), were utilized previously as a source of S-30 preparations...