Radoslav Janicek
Overview
Explore the profile of Radoslav Janicek including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
110
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Recent Articles
1.
Janicek R, Camors E, Potenza D, Fernandez-Tenorio M, Zhao Y, Dooge H, et al.
J Physiol
. 2024 Sep;
602(20):5179-5201.
PMID: 39316734
During exercise or stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor (β-AR) activation, resulting in phosphorylation of the cardiac ryanodine receptor (RyR2). Three RyR2 phosphorylation sites have taken...
2.
Dotti P, Fernandez-Tenorio M, Janicek R, Marquez-Neila P, Wullschleger M, Sznitman R, et al.
Cell Calcium
. 2024 May;
121:102893.
PMID: 38701707
The release of Ca ions from intracellular stores plays a crucial role in many cellular processes, acting as a secondary messenger in various cell types, including cardiomyocytes, smooth muscle cells,...
3.
Egger C, Fernandez-Tenorio M, Blanch J, Janicek R, Egger M
J Mol Cell Cardiol
. 2023 Nov;
186:107-110.
PMID: 37993093
In heart muscle, the physiological function of IP-induced Ca release (IPICR) from the sarcoplasmic reticulum (SR) is still the subject of intense study. A role of IPICR may reside in...
4.
Lopez R, Janicek R, Fernandez-Tenorio M, Courtehoux M, Matas L, Gerbaud P, et al.
J Mol Cell Cardiol
. 2022 Jun;
170:1-14.
PMID: 35644481
Mutations of the RyR2 are channelopathies that can predispose to life threatening catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress. However, the cellular and molecular mechanisms that are causal...
5.
The yin and yang of intracellular delivery of amphipathic optical probes using -butyl charge masking
Agarwal H, Janicek R, Zhao J, Sambath K, Egger M, Niggli E, et al.
Chem Commun (Camb)
. 2022 Feb;
58(17):2826-2829.
PMID: 35112125
Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a core method for cell physiology. Since all these probes have...
6.
Janicek R, Agarwal H, Gomez A, Egger M, Ellis-Davies G, Niggli E
J Physiol
. 2021 Jul;
599(16):3841-3852.
PMID: 34245001
Key Points: In cardiac myocytes, subcellular local calcium release signals, calcium sparks, are recruited to form each cellular calcium transient and activate the contractile machinery. Abnormal timing of recovery of...
7.
Potenza D, Janicek R, Fernandez-Tenorio M, Niggli E
J Physiol
. 2020 Jan;
598(6):1131-1150.
PMID: 31943206
Key Points: Increased protein phosphatase 1 (PP-1) activity has been found in end stage human heart failure. Although PP-1 has been extensively studied, a detailed understanding of its role in...
8.
Potenza D, Janicek R, Fernandez-Tenorio M, Camors E, Ramos-Mondragon R, Valdivia H, et al.
J Gen Physiol
. 2018 Dec;
151(2):131-145.
PMID: 30541771
During physical exercise or stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor (β-AR) activation, resulting in protein kinase A (PKA)-mediated phosphorylation of the cardiac ryanodine receptor RyR2. PKA-dependent...
9.
Agarwal H, Janicek R, Chi S, Perry J, Niggli E, Ellis-Davies G
J Am Chem Soc
. 2016 Mar;
138(11):3687-93.
PMID: 26974387
We have designed a nitroaromatic photochemical protecting group that absorbs visible light in the violet-blue range. The chromophore is a dinitro derivative of bisstyrylthiophene (or BIST) that absorbs light very...
10.
Kyrychenko V, Polakova E, Janicek R, Shirokova N
Cell Calcium
. 2015 May;
58(2):186-95.
PMID: 25975620
Duchenne muscular dystrophy (DMD) is a progressive muscle disease with severe cardiac complications. It is believed that cellular oxidative stress and augmented Ca(2+) signaling drives the development of cardiac pathology....