Graham C R Ellis-Davies
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Explore the profile of Graham C R Ellis-Davies including associated specialties, affiliations and a list of published articles.
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78
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4732
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Recent Articles
1.
Jacobson K, Ellis-Davies G
JACS Au
. 2025 Jan;
5(1):3-16.
PMID: 39886589
Abraham Patchornik was born in 1926 in Ness Ziona, a town in Palestine founded by his great-grandfather Reuben Lehrer in 1883. He started to study chemistry as an undergraduate at...
2.
Zhai S, Otsuka S, Xu J, Clarke V, Tkatch T, Wokosin D, et al.
Cell Rep
. 2024 Jul;
43(8):114540.
PMID: 39058595
Long-term synaptic plasticity at glutamatergic synapses on striatal spiny projection neurons (SPNs) is central to learning goal-directed behaviors and habits. Our studies reveal that SPNs manifest a heterosynaptic, nitric oxide...
3.
Zhai S, Otsuka S, Xu J, Clarke V, Tkatch T, Wokosin D, et al.
bioRxiv
. 2024 May;
PMID: 38712260
Long-term synaptic plasticity at glutamatergic synapses on striatal spiny projection neurons (SPNs) is central to learning goal-directed behaviors and habits. Although considerable attention has been paid to the mechanisms underlying...
4.
Sansalone L, Zhao J, Nguyen L, Gupta S, Benson D, Abe M, et al.
Angew Chem Int Ed Engl
. 2024 Feb;
63(13):e202315726.
PMID: 38329885
We have developed a photochemical protecting group that enables wavelength selective uncaging using green versus violet light. Change of the exocyclic oxygen of the laser dye coumarin-102 to sulfur, gave...
5.
Ellis-Davies G
Angew Chem Int Ed Engl
. 2023 Jan;
62(9):e202206083.
PMID: 36646644
Light passes through biological tissue, and so it is used for imaging biological processes in situ. Such observation is part of the very essence of science, but mechanistic understanding requires...
6.
Thapaliya E, Mony L, Sanchez R, Serraz B, Paoletti P, Ellis-Davies G
ChemPhotoChem
. 2022 Dec;
5(5):445-454.
PMID: 36540756
Ifenprodil is an important negative allosteric modulator of the N-methyl-D-aspartate (NMDA) receptors. We have synthesized caged and photoswitchable derivatives of this small molecule drug. Caged ifenprodil was biologically inert before...
7.
Bossi S, Dhanasobhon D, Ellis-Davies G, Frontera J, de Brito Van Velze M, Lourenco J, et al.
Neuron
. 2022 Jun;
110(15):2438-2454.e8.
PMID: 35700736
GluN3A is an atypical glycine-binding subunit of NMDA receptors (NMDARs) whose actions in the brain are mostly unknown. Here, we show that the expression of GluN3A subunits controls the excitability...
8.
The yin and yang of intracellular delivery of amphipathic optical probes using -butyl charge masking
Agarwal H, Janicek R, Zhao J, Sambath K, Egger M, Niggli E, et al.
Chem Commun (Camb)
. 2022 Feb;
58(17):2826-2829.
PMID: 35112125
Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a core method for cell physiology. Since all these probes have...
9.
Janicek R, Agarwal H, Gomez A, Egger M, Ellis-Davies G, Niggli E
J Physiol
. 2021 Jul;
599(16):3841-3852.
PMID: 34245001
Key Points: In cardiac myocytes, subcellular local calcium release signals, calcium sparks, are recruited to form each cellular calcium transient and activate the contractile machinery. Abnormal timing of recovery of...
10.
Zhao J, Ellis-Davies G
Chem Commun (Camb)
. 2020 Aug;
56(66):9445-9448.
PMID: 32761019
Photoswitchable drugs are small-molecule optical probes that undergo chromatically selective control of drug efficacy using, most often, UV-visible light. Here we report that luminescence produced by near-infrared stimulation of NaYF4:TmYb...