Marcel Egger
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Explore the profile of Marcel Egger including associated specialties, affiliations and a list of published articles.
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28
Citations
332
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Recent Articles
1.
Janicek R, Camors E, Potenza D, Fernandez-Tenorio M, Zhao Y, Dooge H, et al.
J Physiol
. 2024 Sep;
602(20):5179-5201.
PMID: 39316734
During exercise or stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor (β-AR) activation, resulting in phosphorylation of the cardiac ryanodine receptor (RyR2). Three RyR2 phosphorylation sites have taken...
2.
Dotti P, Fernandez-Tenorio M, Janicek R, Marquez-Neila P, Wullschleger M, Sznitman R, et al.
Cell Calcium
. 2024 May;
121:102893.
PMID: 38701707
The release of Ca ions from intracellular stores plays a crucial role in many cellular processes, acting as a secondary messenger in various cell types, including cardiomyocytes, smooth muscle cells,...
3.
Egger C, Fernandez-Tenorio M, Blanch J, Janicek R, Egger M
J Mol Cell Cardiol
. 2023 Nov;
186:107-110.
PMID: 37993093
In heart muscle, the physiological function of IP-induced Ca release (IPICR) from the sarcoplasmic reticulum (SR) is still the subject of intense study. A role of IPICR may reside in...
4.
Lopez R, Janicek R, Fernandez-Tenorio M, Courtehoux M, Matas L, Gerbaud P, et al.
J Mol Cell Cardiol
. 2022 Jun;
170:1-14.
PMID: 35644481
Mutations of the RyR2 are channelopathies that can predispose to life threatening catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress. However, the cellular and molecular mechanisms that are causal...
5.
The yin and yang of intracellular delivery of amphipathic optical probes using -butyl charge masking
Agarwal H, Janicek R, Zhao J, Sambath K, Egger M, Niggli E, et al.
Chem Commun (Camb)
. 2022 Feb;
58(17):2826-2829.
PMID: 35112125
Monitoring and manipulation of ionized intracellular calcium concentrations within intact, living cells using optical probes with organic chromophores is a core method for cell physiology. Since all these probes have...
6.
Janicek R, Agarwal H, Gomez A, Egger M, Ellis-Davies G, Niggli E
J Physiol
. 2021 Jul;
599(16):3841-3852.
PMID: 34245001
Key Points: In cardiac myocytes, subcellular local calcium release signals, calcium sparks, are recruited to form each cellular calcium transient and activate the contractile machinery. Abnormal timing of recovery of...
7.
Illaste A, Wullschleger M, Fernandez-Tenorio M, Niggli E, Egger M
Biophys J
. 2019 Jan;
116(3):383-394.
PMID: 30638961
Analysis of Ca signals obtained in various cell types (i.e., cardiomyocytes) is always a tradeoff between acquisition speed and signal/noise ratio of the fluorescence signal. This becomes especially apparent during...
8.
Blanch I Salvador J, Egger M
J Physiol
. 2018 Jul;
596(18):4323-4340.
PMID: 30004117
Key Points: Augmented inositol 1,4,5-trisphosphate (IP ) receptor (IP R2) expression has been linked to a variety of cardiac pathologies. Although cardiac IP R2 function has been in the focus...
9.
Wullschleger M, Blanch J, Egger M
Cardiovasc Res
. 2017 Feb;
113(5):542-552.
PMID: 28158491
Aims: Enhanced inositol 1,4,5-trisphosphate receptor (InsP3R2) expression has been associated with a variety of proarrhythmogenic cardiac disorders. The functional interaction between the two major Ca2+ release mechanisms in cardiomyocytes, Ca2+ ...
10.
Wullschleger M, Aghlmandi S, Egger M, Zwahlen M
PLoS One
. 2014 Oct;
9(10):e110364.
PMID: 25354300
Rationale: In biomedical journals authors sometimes use the standard error of the mean (SEM) for data description, which has been called inappropriate or incorrect. Objective: To assess the frequency of...