Radim Osicka
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Explore the profile of Radim Osicka including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Khaliq H, Osickova A, Lichvarova M, Sulc M, Navarrete K, Espinosa-Vinals C, et al.
Biochimie
. 2025 Jan;
PMID: 39746438
Kingella kingae, an emerging pediatric pathogen, secretes the pore-forming toxin RtxA, which has been implicated in the development of various invasive infections. RtxA is synthesized as a protoxin (proRtxA), which...
2.
Ruzickova E, Lichvarova M, Osickova A, Filipi K, Jurnecka D, Khaliq H, et al.
Int J Biol Macromol
. 2024 Nov;
283(Pt 1):137604.
PMID: 39542310
The RtxA cytotoxin, a member of the RTX (Repeats in ToXin) family of pore-forming toxins, is the primary virulence factor of the paediatric facultative pathogen Kingella kingae. Although structure-function studies...
3.
Kuchar M, Sloupenska K, Raskova Kafkova L, Groza Y, Skarda J, Kosztyu P, et al.
Cell Commun Signal
. 2024 Oct;
22(1):469.
PMID: 39354587
Background: Human interleukin-22 (IL-22) is known as a "dual function" cytokine that acts as a master regulator to maintain homeostasis, structural integrity of the intestinal epithelial barrier, and shielding against...
4.
Groza Y, Lacina L, Kuchar M, Raskova Kafkova L, Zachova K, Janouskova O, et al.
Cell Commun Signal
. 2024 May;
22(1):261.
PMID: 38715108
Background: Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune diseases. Signaling via its cognate IL-6 receptor...
5.
Lepesheva A, Grobarcikova M, Osickova A, Jurnecka D, Knoblochova S, Cizkova M, et al.
Biochim Biophys Acta Biomembr
. 2024 Apr;
1866(5):184311.
PMID: 38570122
The acylated pore-forming Repeats in ToXin (RTX) cytolysins α-hemolysin (HlyA) and adenylate cyclase toxin (CyaA) preferentially bind to β integrins of myeloid leukocytes but can also promiscuously bind and permeabilize...
6.
Gruper Y, Wolff A, Glanz L, Spoutil F, Marthinussen M, Osickova A, et al.
Nature
. 2023 Nov;
624(7992):653-662.
PMID: 37993717
Ameloblasts are specialized epithelial cells in the jaw that have an indispensable role in tooth enamel formation-amelogenesis. Amelogenesis depends on multiple ameloblast-derived proteins that function as a scaffold for hydroxyapatite...
7.
Wu Y, Du S, Bimler L, Mauk K, Lortal L, Kichik N, et al.
Cell Rep
. 2023 Oct;
42(10):113240.
PMID: 37819761
The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. ...
8.
Osickova A, Knoblochova S, Bumba L, Man P, Kalaninova Z, Lepesheva A, et al.
J Biol Chem
. 2023 Jun;
299(8):104978.
PMID: 37390987
The acylated Repeats in ToXins (RTX) leukotoxins, the adenylate cyclase toxin (CyaA) or α-hemolysin (HlyA), bind β integrins of leukocytes but also penetrate cells lacking these receptors. We show that...
9.
Rahman W, Fiser R, Osicka R
Microb Pathog
. 2023 Jun;
181:106200.
PMID: 37315629
The membrane-damaging RTX family cytotoxin RtxA is a key virulence factor of the emerging pediatric pathogen Kingella kingae, but little is known about the mechanism of RtxA binding to host...
10.
Spoutil F, Aranaz-Novaliches G, Prochazkova M, Wald T, Novosadova V, Kasparek P, et al.
Sci Rep
. 2023 Jan;
13(1):1471.
PMID: 36702824
Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in odontogenic tissues and diverged from common ancestral gene. They are crucial for the maturation of enamel and its extreme complexity...