Ladislav Bumba
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Explore the profile of Ladislav Bumba including associated specialties, affiliations and a list of published articles.
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Articles
58
Citations
1024
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Recent Articles
1.
Slivenecka E, Jurnecka D, Holubova J, Stanek O, Brazdilova L, Cizkova M, et al.
Microbiol Res
. 2024 Dec;
292():128043.
PMID: 39740637
The ApxIVA protein belongs to a distinct class of a "clip and link" activity of Repeat-in-ToXin (RTX) exoproteins. Along with the three other pore-forming RTX toxins (ApxI, ApxII and ApxIII),...
2.
Chen G, Wang H, Bumba L, Masin J, Sebo P, Li H
J Biol Chem
. 2023 Aug;
299(9):105150.
PMID: 37567473
Folding of the Repeats-in-toxin (RTX) domain of the bacterial adenylate cyclase toxin-hemolysin (CyaA) is critical to its toxin activities and the virulence of the whooping cough agent Bordetella pertussis. The...
3.
Osickova A, Knoblochova S, Bumba L, Man P, Kalaninova Z, Lepesheva A, et al.
J Biol Chem
. 2023 Jun;
299(8):104978.
PMID: 37390987
The acylated Repeats in ToXins (RTX) leukotoxins, the adenylate cyclase toxin (CyaA) or α-hemolysin (HlyA), bind β integrins of leukocytes but also penetrate cells lacking these receptors. We show that...
4.
Navarrete K, Bumba L, Prudnikova T, Malcova I, Allsop T, Sebo P, et al.
Microbiol Spectr
. 2023 Apr;
11(3):e0411222.
PMID: 37036369
The classical species infect the respiratory tract of mammals. While B. bronchiseptica causes rather chronic respiratory infections in a variety of mammals, the human-adapted species B. pertussis and cause an...
5.
Hovorkova M, cerveny J, Bumba L, Pelantova H, Cvacka J, Kren V, et al.
Bioorg Chem
. 2022 Nov;
131:106279.
PMID: 36446202
Galectins are proteins of the family of human lectins. By binding terminal galactose units of cell surface glycans, they moderate biological and pathological processes such as cell signaling, cell adhesion,...
6.
Felix J, Bumba L, Liesche C, Fraudeau A, Rebeille F, El Khoury J, et al.
Nat Commun
. 2022 Sep;
13(1):5502.
PMID: 36127320
Enteric bacteria have to adapt to environmental stresses in the human gastrointestinal tract such as acid and nutrient stress, oxygen limitation and exposure to antibiotics. Membrane lipid composition has recently...
7.
Klimova N, Holubova J, Streparola G, Tomala J, Brazdilova L, Stanek O, et al.
PLoS Pathog
. 2022 Jun;
18(6):e1010577.
PMID: 35666769
The adenylate cyclase (ACT) and the pertussis (PT) toxins of Bordetella pertussis exert potent immunomodulatory activities that synergize to suppress host defense in the course of whooping cough pathogenesis. We...
8.
Vrbata D, Filipova M, Tavares M, cerveny J, Vlachova M, Sirova M, et al.
J Med Chem
. 2022 Feb;
65(5):3866-3878.
PMID: 35157467
Galectin-3 (Gal-3) participates in many cancer-related metabolic processes. The inhibition of overexpressed Gal-3 by, e.g., β-galactoside-derived inhibitors is hence promising for cancer treatment. The multivalent presentation of such inhibitors on...
9.
Lepesheva A, Osickova A, Holubova J, Jurnecka D, Knoblochova S, Espinosa-Vinals C, et al.
Sci Rep
. 2021 Oct;
11(1):19814.
PMID: 34615931
Pore-forming repeats in toxins (RTX) are key virulence factors of many Gram-negative pathogens. We have recently shown that the aromatic side chain of the conserved tyrosine residue 940 within the...
10.
Espinosa-Vinals C, Masin J, Holubova J, Stanek O, Jurnecka D, Osicka R, et al.
J Biol Chem
. 2021 May;
297(1):100833.
PMID: 34051233
The whooping cough agent Bordetella pertussis secretes an adenylate cyclase toxin (CyaA) that through its large carboxy-proximal Repeat-in-ToXin (RTX) domain binds the complement receptor 3 (CR3). The RTX domain consists...