Adriana Osickova
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Explore the profile of Adriana Osickova including associated specialties, affiliations and a list of published articles.
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26
Citations
319
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Recent Articles
1.
Khaliq H, Osickova A, Lichvarova M, Sulc M, Navarrete K, Espinosa-Vinals C, et al.
Biochimie
. 2025 Jan;
PMID: 39746438
Kingella kingae, an emerging pediatric pathogen, secretes the pore-forming toxin RtxA, which has been implicated in the development of various invasive infections. RtxA is synthesized as a protoxin (proRtxA), which...
2.
Ruzickova E, Lichvarova M, Osickova A, Filipi K, Jurnecka D, Khaliq H, et al.
Int J Biol Macromol
. 2024 Nov;
283(Pt 1):137604.
PMID: 39542310
The RtxA cytotoxin, a member of the RTX (Repeats in ToXin) family of pore-forming toxins, is the primary virulence factor of the paediatric facultative pathogen Kingella kingae. Although structure-function studies...
3.
Lepesheva A, Grobarcikova M, Osickova A, Jurnecka D, Knoblochova S, Cizkova M, et al.
Biochim Biophys Acta Biomembr
. 2024 Apr;
1866(5):184311.
PMID: 38570122
The acylated pore-forming Repeats in ToXin (RTX) cytolysins α-hemolysin (HlyA) and adenylate cyclase toxin (CyaA) preferentially bind to β integrins of myeloid leukocytes but can also promiscuously bind and permeabilize...
4.
Gruper Y, Wolff A, Glanz L, Spoutil F, Marthinussen M, Osickova A, et al.
Nature
. 2023 Nov;
624(7992):653-662.
PMID: 37993717
Ameloblasts are specialized epithelial cells in the jaw that have an indispensable role in tooth enamel formation-amelogenesis. Amelogenesis depends on multiple ameloblast-derived proteins that function as a scaffold for hydroxyapatite...
5.
Osickova A, Knoblochova S, Bumba L, Man P, Kalaninova Z, Lepesheva A, et al.
J Biol Chem
. 2023 Jun;
299(8):104978.
PMID: 37390987
The acylated Repeats in ToXins (RTX) leukotoxins, the adenylate cyclase toxin (CyaA) or α-hemolysin (HlyA), bind β integrins of leukocytes but also penetrate cells lacking these receptors. We show that...
6.
Golshani M, Rahman W, Osickova A, Holubova J, Lora J, Balashova N, et al.
Int J Mol Sci
. 2022 Oct;
23(20).
PMID: 36293453
The pertussis agent produces a number of virulence factors, of which the filamentous hemagglutinin (FhaB) plays a role in adhesion to epithelial and phagocytic cells. Moreover, FhaB was recently found...
7.
Filipi K, Rahman W, Osickova A, Osicka R
Microorganisms
. 2022 Mar;
10(3).
PMID: 35336094
The Gram-negative bacterium is part of the commensal oropharyngeal flora of young children. As detection methods have improved, has been increasingly recognized as an emerging invasive pathogen that frequently causes...
8.
Holubova J, Juhasz A, Masin J, Stanek O, Jurnecka D, Osickova A, et al.
Int J Mol Sci
. 2021 Nov;
22(21).
PMID: 34769101
The whooping cough agent, , secretes an adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) that catalyzes the conversion of intracellular ATP to cAMP and through its signaling annihilates the bactericidal...
9.
Lepesheva A, Osickova A, Holubova J, Jurnecka D, Knoblochova S, Espinosa-Vinals C, et al.
Sci Rep
. 2021 Oct;
11(1):19814.
PMID: 34615931
Pore-forming repeats in toxins (RTX) are key virulence factors of many Gram-negative pathogens. We have recently shown that the aromatic side chain of the conserved tyrosine residue 940 within the...
10.
Malandra A, Rahman W, Klimova N, Streparola G, Holubova J, Osickova A, et al.
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445770
The mucus layer protects airway epithelia from damage by noxious agents. Intriguingly, bacteria provoke massive mucus production by nasopharyngeal epithelia during the initial coryza-like catarrhal stage of human pertussis and...