Radim Nencka
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Explore the profile of Radim Nencka including associated specialties, affiliations and a list of published articles.
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84
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1353
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Recent Articles
11.
Zgarbova M, Otava T, Silhan J, Nencka R, Weber J, Boura E
Antiviral Res
. 2023 Sep;
218:105714.
PMID: 37689311
The RNA 2'-O methyltransferase (MTase) VP39 of the monkeypox virus (MpxV) participates in RNA capping within poxviruses. Sub-micromolar inhibitors targeting this enzyme were already reported. However, these 7-deaza analogs of...
12.
Misehe M, Matousova M, Dvorakova A, Hercik K, Skach K, Chalupska D, et al.
Eur J Med Chem
. 2023 Aug;
260:115717.
PMID: 37598483
Receptor-interacting protein kinases 2 and 3 (RIPK2 and RIPK3) are considered attractive therapeutic enzyme targets for the treatment of a multitude of inflammatory diseases and cancers. In this study, we...
13.
Dejmek M, Brazdova A, Otava T, Polidarova M, Klima M, Smola M, et al.
Eur J Med Chem
. 2023 Aug;
259:115685.
PMID: 37567057
Cyclic dinucleotides (CDNs) trigger the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, which plays a key role in cytosolic DNA sensing and thus in immunomodulation against infections, cell damage...
14.
Stefek M, Chalupska D, Chalupsky K, Zgarbova M, Dvorakova A, Krafcikova P, et al.
ACS Omega
. 2023 Aug;
8(30):27410-27418.
PMID: 37546609
The search for new drugs against COVID-19 and its causative agent, SARS-CoV-2, is one of the major trends in the current medicinal chemistry. Targeting capping machinery could be one of...
15.
Brehova P, Reznickova E, Skach K, Jorda R, Dejmek M, Vojackova V, et al.
J Med Chem
. 2023 Aug;
66(16):11133-11157.
PMID: 37535845
FLT3 kinase is a potential drug target in acute myeloid leukemia (AML). Patients with FLT3 mutations typically have higher relapse rates and worse outcomes than patients without FLT3 mutations. In...
16.
Nuta G, Gilad Y, Goldberg N, Meril S, Bahlsen M, Carvalho S, et al.
Autophagy
. 2023 May;
19(8):2372-2385.
PMID: 37184247
Macroautophagy/autophagy is a catabolic process by which cytosolic content is engulfed, degraded and recycled. It has been implicated as a critical pathway in advanced stages of cancer, as it maintains...
17.
Silhan J, Klima M, Otava T, Skvara P, Chalupska D, Chalupsky K, et al.
Nat Commun
. 2023 Apr;
14(1):2259.
PMID: 37080993
Monkeypox is a disease with pandemic potential. It is caused by the monkeypox virus (MPXV), a double-stranded DNA virus from the Poxviridae family, that replicates in the cytoplasm and must...
18.
Mejdrova I, Dusek J, Skach K, Stefela A, Skoda J, Chalupsky K, et al.
J Med Chem
. 2023 Feb;
66(4):2422-2456.
PMID: 36756805
The nuclear constitutive androstane receptor (CAR, NR1I3) plays significant roles in many hepatic functions, such as fatty acid oxidation, biotransformation, liver regeneration, as well as clearance of steroid hormones, cholesterol,...
19.
Chambers C, Cermakova K, Chan Y, Kurtz K, Wohlan K, Lewis A, et al.
Cancer Res
. 2023 Jan;
83(7):983-996.
PMID: 36662812
Significance: Disruption of PU.1-directed enhancer programs upon SWI/SNF inhibition causes differentiation of AML cells and induces leukopenia of PU.1-dependent B cells and monocytes, revealing the on- and off-tumor effects of...
20.
Misehe M, Klima M, Matousova M, Chalupska D, Dejmek M, Sala M, et al.
Bioorg Med Chem Lett
. 2022 Oct;
76:129010.
PMID: 36184029
Novel 4-aminoquinazoline-6-carboxamide derivatives bearing differently substituted aryl or heteroaryl groups at position 7 in the core were rationally designed, synthesized and evaluated for biological activity in vitro as phosphatidylinositol 4-kinase...