R W Colman
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Explore the profile of R W Colman including associated specialties, affiliations and a list of published articles.
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487
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3736
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Recent Articles
1.
Pixley R, Espinola R, Ghebrehiwet B, Joseph K, Kao A, Bdeir K, et al.
Thromb Haemost
. 2011 May;
105(6):1053-9.
PMID: 21544310
The physiologic activation of the plasma kallikrein-kinin system requires the assembly of its constituents on a cell membrane. High- molecular-weight kininogen (HK) and cleaved HK (HKa) both interact with at...
2.
3.
Sheth S, Colman R
Platelets
. 2010 Nov;
6(2):61-70.
PMID: 21043695
Platelets respond to a wide variety of exogenous agonists that bind to distinct receptors on the platelet surface resulting in the intracellular generation of second messengers or the opening of...
4.
Wu Y, Dai J, Schmuckler N, Bakdash N, Yoder M, Overall C, et al.
J Thromb Haemost
. 2009 Oct;
8(1):185-93.
PMID: 19874467
Background And Objective: Endothelial progenitor cells (EPCs) contribute to postnatal neovascularization, thus promoting wide interest in their therapeutic potential in vascular injury and prevention of their dysfunction in cardiovascular diseases....
5.
Liu Y, Pixley R, Fusaro M, Godoy G, Kim E, Bromberg M, et al.
Oncogene
. 2009 Jun;
28(30):2756-65.
PMID: 19483730
Upregulation and activation of epidermal growth factor receptor and/or urokinase-type plasminogen activator receptor in a variety of cancers have been shown to be associated with poor prognosis. High-molecular-weight kininogen can...
6.
Bior A, Pixley R, Colman R
J Thromb Haemost
. 2006 Dec;
5(2):403-11.
PMID: 17155949
Background: Domain 5 (D5) of kininogen inhibits endothelial cell adhesion, migration, proliferation and angiogenesis by inducing apoptosis and disrupting a signaling pathway initiated by binding to the urokinase receptor (uPAR)....
7.
Devani M, Vecchi M, Ferrero S, Contessini Avesani E, Arizzi C, Chao L, et al.
Dig Liver Dis
. 2005 Jun;
37(9):665-73.
PMID: 15949977
Background: Tissue kallikrein and its natural inhibitor, kallistatin, play opposite roles in the generation of bradykinin, a potent mediator of inflammation. Observations on experimental models and humans with ulcerative colitis...
8.
Guo Y, Colman R
J Thromb Haemost
. 2005 Mar;
3(4):670-6.
PMID: 15733059
High-molecular-weight kininogen (HK) is a plasma protein that possesses multiple physiological functions. Originally identified as a precursor of bradykinin, a bioactive peptide that regulates many cardiovascular processes, it is now...
9.
Sainz I, Uknis A, Isordia-Salas I, Dela Cadena R, Pixley R, Colman R
FASEB J
. 2004 Mar;
18(7):887-9.
PMID: 15001555
Bradykinin (BK), a vasoactive, proinflammatory nonapeptide, promotes cell adhesion molecule (CAM) expression, leukocyte sequestration, inter-endothelial gap formation, and protein extravasation in postcapillary venules. These effects are mediated by bradykinin-1 (B1R)...
10.
Pixley R, Lin Y, Isordia-Salas I, Colman R
J Thromb Haemost
. 2003 Aug;
1(8):1791-8.
PMID: 12911595
We previously localized the heparin binding region on high molecular weight kininogen to domain 5 (D5) by quantifying the binding using surface plasmon resonance of D5 fused at its N-terminal...