R N Puri
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Explore the profile of R N Puri including associated specialties, affiliations and a list of published articles.
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44
Citations
207
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Recent Articles
1.
Puri R
Biochem Pharmacol
. 1999 Mar;
57(8):851-9.
PMID: 10086317
ADP is the oldest and one of the most important agonists of platelet activation. ADP induces platelet shape change, exposure of fibrinogen binding sites, aggregation, and influx and intracellular mobilization...
2.
Puri R
Int J Biochem Cell Biol
. 1998 Oct;
30(10):1107-22.
PMID: 9785476
ADP and thrombin are two of the most important agonists of platelet aggregation--a cellular response that is critical for maintaining normal hemostasis. However, aberrant platelet aggregation induced by these agonists...
3.
Puri R, Colman R
J Protein Chem
. 1998 Aug;
17(5):429-51.
PMID: 9717739
Platelet aggregation is important for maintaining normal hemostasis. However, aberrant platelet aggregation plays a major role in acute coronary artery diseases, myocardial infarction, unstable angina, and stroke. ADP is one...
4.
Puri R, Colman R
Arch Biochem Biophys
. 1997 Dec;
347(2):263-70.
PMID: 9367534
The ADP-receptor on the surface of human platelets and cells of megakaryocytic lineage has been classified as P2T purinergic receptor for which ADP is an agonist and ATP is an...
5.
Puri R, Colman R, Colman R
Arch Biochem Biophys
. 1997 Jul;
343(1):140-5.
PMID: 9210656
The 2-substituted ADP derivatives are known to activate human blood platelets with varying degrees of potency. For example, 2-(4-bromo-2,3-dioxobutylthio)adenosine-5'-diphosphate [2-BDB-TADP], an ADP-affinity analog, was previously shown by us to be...
6.
Puri R, Colman R
Crit Rev Biochem Mol Biol
. 1997 Jan;
32(6):437-502.
PMID: 9444477
Platelet activation is central to the pathogenesis of hemostasis and arterial thrombosis. Platelet aggregation plays a major role in acute coronary artery diseases, myocardial infarction, unstable angina, and stroke. ADP...
7.
Puri R, Colman R
Anal Biochem
. 1996 Sep;
240(2):251-61.
PMID: 8811919
The chemical reaction of N-ethyl-5-phenylisooxazolium-3'-sulfonate (Woodward's Reagent-K, WR-K) with a carboxyl group yields an enol ester that cannot be reduced by sodium borohydride in an aqueous solution, while other nucleophiles...
8.
Puri R, Colman R
J Cell Biochem
. 1996 Apr;
61(1):97-108.
PMID: 8726359
ADP-induced platelet responses play an important role in the maintenance of hemostasis. There has been disagreement concerning the identity of an ADP receptor on the platelet surface. The chemical structure...
9.
Puri R, Colman R, Colman R
Eur J Biochem
. 1996 Mar;
236(3):862-70.
PMID: 8665907
Platelet responses induced by ADP are mediated by a unique P21-purinergic receptor. Although a variety of ADP analogs, substituted at C2, have been used to delineate pharmacological properties of the...
10.
Puri R, Kumar A, Chen H, Colman R, Colman R
J Biol Chem
. 1995 Oct;
270(41):24482-8.
PMID: 7592664
ADP is an important platelet agonist which initiates platelet shape change, aggregation, exposure of fibrinogen receptors, and calcium mobilization. Because of the limitations of previously used affinity analogs and photo-labeling...