R T Simpson
Overview
Explore the profile of R T Simpson including associated specialties, affiliations and a list of published articles.
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Articles
111
Citations
2788
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Recent Articles
1.
Wang X, Simpson R
Nucleic Acids Res
. 2001 May;
29(9):1943-50.
PMID: 11328878
Most methods for assessment of chromatin structure involve chemical or nuclease damage to DNA followed by analysis of distribution and susceptibility of cutting sites. The agents used generally do not...
2.
Tup1p represses Mcm1p transcriptional activation and chromatin remodeling of an a-cell-specific gene
Gavin I, Kladde M, Simpson R
EMBO J
. 2000 Nov;
19(21):5875-83.
PMID: 11060038
In yeast, a number of regulatory proteins expressed only in specific cell types interact with general transcription factors in a combinatorial manner to control expression of cell-type-specific genes. We report...
3.
Kladde M, Xu M, Simpson R
Methods Mol Biol
. 2000 May;
119:395-416.
PMID: 10804528
No abstract available.
4.
Ducker C, Simpson R
EMBO J
. 2000 Feb;
19(3):400-9.
PMID: 10654939
In yeast alpha cells the a cell-specific genes STE6 and BAR1 are packaged as gene-sized chromatin domains of positioned nucleosomes. Organized chromatin depends on Tup1p, a corepressor that interacts with...
5.
Ravindra A, Weiss K, Simpson R
Mol Cell Biol
. 1999 Nov;
19(12):7944-50.
PMID: 10567520
Genetic and biochemical evidence implicates chromatin structure in the silencing of the two quiescent mating-type loci near the telomeres of chromosome III in yeast. With high-resolution micrococcal nuclease mapping, we...
6.
Kladde M, Xu M, Simpson R
Methods Enzymol
. 1999 Jun;
304:431-47.
PMID: 10372375
No abstract available.
7.
Simpson R
Curr Opin Genet Dev
. 1999 May;
9(2):225-9.
PMID: 10322144
A groundswell of interest in chromatin structure and its role in regulating the function of DNA in transcription, replication, recombination and repair has developed in the past decade. Fueled by...
8.
Simpson R
Methods
. 1998 Sep;
15(4):283-94.
PMID: 9740716
Some transcriptional repressors appear to organize chromatin structure as at least part of their mechanism. Some transcriptional activators appear to alter or remodel chromatin structure as at least part of...
9.
Weiss K, Simpson R
Mol Cell Biol
. 1998 Aug;
18(9):5392-403.
PMID: 9710623
Genetic studies have suggested that chromatin structure is involved in repression of the silent mating type loci in Saccharomyces cerevisiae. Chromatin mapping at nucleotide resolution of the transcriptionally silent HMLalpha...
10.
Xu M, Kladde M, Van Etten J, Simpson R
Nucleic Acids Res
. 1998 Aug;
26(17):3961-6.
PMID: 9705505
A novel gene encoding a cytosine-5-DNA methyltransferase recognizing the dinucleotide GpC was cloned from Chlorella virus NYs-1 and expressed in both Escherichia coli and Saccharomyces cerevisiae . The gene was...