R T Layer
Overview
Explore the profile of R T Layer including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
21
Citations
348
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Layer R
Curr Protoc Neurosci
. 2008 Apr;
Chapter 7:Unit7.7.
PMID: 18428533
The use of filtration assays is often unsuitable for radioligands with rapid dissociation rates. Rapid dissociation may result in the loss of significant amounts of bound ligand during the separation...
2.
Adams A, Layer R, McCabe R, Keefe K
Eur J Pharmacol
. 2000 Sep;
404(3):303-13.
PMID: 10996596
Conantokins, peptides from Conus snails, are N-methyl-D-aspartate (NMDA) receptor antagonists. NMDA receptor antagonists potentiate L-3,4-dihydroxyphenylalanine (L-DOPA)-induced rotation in 6-hydroxydopamine-treated rodents, an index of anti-Parkinsonian potential. This study examined the effects...
3.
McIntosh J, Corpuz G, Layer R, Garrett J, Wagstaff J, Bulaj G, et al.
J Biol Chem
. 2000 Jul;
275(42):32391-7.
PMID: 10900201
Cone snails are tropical marine mollusks that envenomate prey with a complex mixture of neuropharmacologically active compounds. We report the discovery and biochemical characterization of a structurally unique peptide isolated...
4.
McCabe R, Sofia R, Layer R, Leiner K, Faull R, Narang N, et al.
J Pharmacol Exp Ther
. 1998 Aug;
286(2):991-9.
PMID: 9694960
The anticonvulsant compound felbamate (2-phenyl-1,3-propanediol dicarbamate; FBM) appears to inhibit the function of the N-methyl-D-aspartate (NMDA) receptor complex through an interaction with the strychnine-insensitive glycine recognition site. Since we have...
5.
Huang N, Strakhova M, Layer R, Skolnick P
J Mol Neurosci
. 1998 Mar;
9(3):167-76.
PMID: 9481618
Antidepressant therapies include drugs with a remarkable structural diversity and non-pharmacological interventions, such as electroconvulsive shock. Although the primary neurochemical effects of these treatments may differ, the > or =...
6.
Hill R, Wallace L, Miller D, Weinstein D, Shams G, Tai H, et al.
J Med Chem
. 1997 Nov;
40(20):3182-91.
PMID: 9379437
Antagonists of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptors may have therapeutic potential as psychotropic agents. A series of mononitro- and dinitro-2- and 3-hydroxyphenylalanines was prepared, and their activity compared with willardiine, 5-nitrowillardiine,...
7.
Layer R, Skolnick P, Bertha C, Bandarage U, KUEHNE M, Popik P
Eur J Pharmacol
. 1996 Aug;
309(2):159-65.
PMID: 8874134
Based on both preclinical findings and anecdotal evidence in man, the psychoactive indole alkaloid ibogaine has been suggested to have anti-addictive properties. Previous studies indicate that blockade of NMDA receptors...
8.
Skolnick P, Layer R, Popik P, Nowak G, Paul I, Trullas R
Pharmacopsychiatry
. 1996 Jan;
29(1):23-6.
PMID: 8852530
NMDA antagonists mimic the effects of clinically effective antidepressants in both preclinical tests predictive of antidepressant action and procedures designed to model aspects of depressive symptomatology. These findings led to...
9.
Layer R, Popik P, Olds T, Skolnick P
Pharmacol Biochem Behav
. 1995 Nov;
52(3):621-7.
PMID: 8545484
Functional N-methyl-D-aspartate (NMDA) antagonists including competitive antagonists, glycine partial agonists, and use-dependent channel blockers exhibit antidepressant-like actions in preclinical models. The present study examined the effects of eliprodil (SL-82.0715), an...
10.
Popik P, Layer R, Fossom L, Benveniste M, Witkin J, Skolnick P
J Pharmacol Exp Ther
. 1995 Nov;
275(2):753-60.
PMID: 7473163
Both anecdotal reports in humans and preclinical studies indicate that ibogaine interrupts addiction to a variety of abused substances including alcohol, opiates, nicotine and stimulants. Based on the similarity of...