R T McCabe
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Explore the profile of R T McCabe including associated specialties, affiliations and a list of published articles.
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36
Citations
316
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Recent Articles
1.
Adams A, Layer R, McCabe R, Keefe K
Eur J Pharmacol
. 2000 Sep;
404(3):303-13.
PMID: 10996596
Conantokins, peptides from Conus snails, are N-methyl-D-aspartate (NMDA) receptor antagonists. NMDA receptor antagonists potentiate L-3,4-dihydroxyphenylalanine (L-DOPA)-induced rotation in 6-hydroxydopamine-treated rodents, an index of anti-Parkinsonian potential. This study examined the effects...
2.
Donevan S, McCabe R
Mol Pharmacol
. 2000 Aug;
58(3):614-23.
PMID: 10953056
Conantokin G (Con G) is a 17-amino-acid peptide antagonist of N-methyl-D-aspartate (NMDA) receptors isolated from the venom of the marine cone snail, Conus geographus. The mechanism of action of Con...
3.
Williams A, Dave J, Phillips J, Lin Y, McCabe R, Tortella F
J Pharmacol Exp Ther
. 2000 Jun;
294(1):378-86.
PMID: 10871336
Conantokin-G (Con-G), a 17-amino-acid peptide derived from marine snails and a potent N-methyl-D-aspartate (NMDA) antagonist, was evaluated for its neuroprotective properties in vitro and in vivo. In primary cerebellar neurons,...
4.
Lian H, Steiner S, Sofia R, Woodhead J, Wolf H, White H, et al.
J Pharm Sci
. 2000 Jun;
89(7):867-75.
PMID: 10861587
Felbamate (FBM) is a novel antiepileptic drug (AED) and neuroprotectant (NP) compound that interacts with strychnine-insensitive (SI) glycine receptors in brain (IC(50) = 374 microM). FBM concentrations required to interact...
5.
White H, McCabe R, Armstrong H, Donevan S, Cruz L, Abogadie F, et al.
J Pharmacol Exp Ther
. 1999 Dec;
292(1):425-32.
PMID: 10604979
The purification, characterization, and synthesis of conantokin-R (Con-R), an N-methyl-D-aspartate (NMDA) receptor peptide antagonist from the venom of Conus radiatus, are described. With the use of well defined animal seizure...
6.
Rogers J, Luginbuhl P, Shen G, McCabe R, Stevens R, Wemmer D
Biochemistry
. 1999 Apr;
38(13):3874-82.
PMID: 10194298
Alpha-Conotoxins, peptides produced by predatory species of Conus marine snails, are potent antagonists of nicotinic acetylcholine receptors (nAChRs), ligand-gated ion channels involved in synaptic transmission. We determined the NMR solution...
7.
McCabe R, Sofia R, Layer R, Leiner K, Faull R, Narang N, et al.
J Pharmacol Exp Ther
. 1998 Aug;
286(2):991-9.
PMID: 9694960
The anticonvulsant compound felbamate (2-phenyl-1,3-propanediol dicarbamate; FBM) appears to inhibit the function of the N-methyl-D-aspartate (NMDA) receptor complex through an interaction with the strychnine-insensitive glycine recognition site. Since we have...
8.
Wamsley J, Sofia R, Faull R, Narang N, Ary T, McCabe R
Exp Neurol
. 1994 Oct;
129(2):244-50.
PMID: 7957739
The dicarbamate felbamate has been shown to be capable of competing for the binding of 5,7-[3H]dichlorokynurenic acid ([3H]DCKA) to strychnine-insensitive glycine receptors in sections of human postmortem brain. The IC50...
9.
Wamsley J, Sofia R, Faull R, Narang N, Ary T, Gan X, et al.
Proc West Pharmacol Soc
. 1994 Jan;
37:81-3.
PMID: 7984680
No abstract available.
10.
Wamsley J, Sofia R, Faull R, Ary T, Narang N, McCabe R
Brain Res Bull
. 1994 Jan;
35(3):205-9.
PMID: 7812798
[3H]5,7 Dichlorokynurenic acid ([3H]DCKA) was used to define conditions for obtaining selective binding to strychnine-insensitive glycine receptors. The parameters were established in sections of human brain prior to localizing the...