P Skolnick
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Explore the profile of P Skolnick including associated specialties, affiliations and a list of published articles.
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397
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Recent Articles
1.
Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, et al.
Proc Natl Acad Sci U S A
. 2005 May;
102(20):7380-5.
PMID: 15870187
Benzodiazepines remain widely used for the treatment of anxiety disorders despite prominent, often limiting side effects including sedation, muscle relaxation, and ataxia. A compound producing a robust anxiolytic action comparable...
2.
Skolnick P
Amino Acids
. 2002 Oct;
23(1-3):153-9.
PMID: 12373530
On a biochemical level, conventional antidepressants have been shown to modulate synaptic levels of biogenic amines (i.e., serotonin, norepinephrine, and dopamine), most often by interfering with reuptake processes or inhibiting...
3.
4.
Bai F, Li X, Clay M, Lindstrom T, Skolnick P
Pharmacol Biochem Behav
. 2001 Nov;
70(2-3):187-92.
PMID: 11701187
In the present studies, base line and drug-induced performance of two mouse strains (C57Bl/6 and NIH-Swiss) was evaluated in the forced swim test (FST) and tail suspension test (TST). Intra-...
5.
Harvey S, Koster A, Yu H, Skolnick P, Baumbarger P, Nisenbaum E
J Mol Neurosci
. 2001 Oct;
17(1):35-43.
PMID: 11665861
The GluR2 subunit of the alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor determines many of the biophysical properties of native AMPA receptors, including Ca++ permeability. Genetically engineered mice unable to edit the Q...
6.
Zarrinmayeh H, Bleakman D, Gates M, Yu H, Zimmerman D, Ornstein P, et al.
J Med Chem
. 2001 Jul;
44(3):302-4.
PMID: 11462971
No abstract available.
7.
Li X, Tizzano J, Griffey K, Clay M, Lindstrom T, Skolnick P
Neuropharmacology
. 2001 Jun;
40(8):1028-33.
PMID: 11406194
LY392098 is a member of a novel class of biarylpropylsulfonamides that potentiates AMPA receptor-mediated responses both in vitro and in vivo. In this study, the effects of LY392098 were evaluated...
8.
Legutko B, Li X, Skolnick P
Neuropharmacology
. 2001 Jun;
40(8):1019-27.
PMID: 11406193
The effects of a novel AMPA receptor potentiator (LY392098) on the expression of brain-derived neurotrophic factor (BDNF) were examined in primary neuron culture. The addition of either AMPA or LY392098...
9.
Linden A, Yu H, Zarrinmayeh H, Wheeler W, Skolnick P
Neuropharmacology
. 2001 Jun;
40(8):1010-8.
PMID: 11406192
LY395153 is a member of a newly described class of arylpropylsulfonamide AMPA receptor potentiators. Here, we characterize and compare [(3)H]LY395153 binding to native AMPA receptors from rat cerebral cortex and...
10.
Skolnick P, Legutko B, Li X, Bymaster F
Pharmacol Res
. 2001 Jun;
43(5):411-23.
PMID: 11394932
Compounds that inhibit the re-uptake and/or metabolism of biogenic amines (i.e. serotonin, norepinephrine, and dopamine) have been used to treat depression for more than 40 years. Selective re-uptake inhibitors, currently...