R Shiekhattar
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Explore the profile of R Shiekhattar including associated specialties, affiliations and a list of published articles.
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27
Citations
1582
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Recent Articles
1.
Cheng G, Liu F, Asai T, Lai F, Man N, Xu H, et al.
Leukemia
. 2016 Nov;
31(6):1382-1390.
PMID: 27881875
The role that changes in DNA methylation and histone modifications have in human malignancies is poorly understood. p300 and CREB-binding protein (CBP), two distinct but highly homologous lysine acetyltransferases, are...
2.
Witt A, Lee C, Lee T, Azzam D, Wang B, Caslini C, et al.
Oncogene
. 2016 Oct;
36(12):1707-1720.
PMID: 27694895
Tumours are comprised of a highly heterogeneous population of cells, of which only a small subset of stem-like cells possess the ability to regenerate tumours in vivo. These cancer stem...
3.
Lai F, Blumenthal E, Shiekhattar R
Methods Enzymol
. 2016 Jul;
573:421-44.
PMID: 27372765
Recent genome-wide studies have yielded new insights into the biological function of long noncoding RNAs (lncRNAs), predominantly through analysis of their genomic addresses. These studies have revealed that a large...
4.
Orom U, Derrien T, Guigo R, Shiekhattar R
Cold Spring Harb Symp Quant Biol
. 2011 Apr;
75:325-31.
PMID: 21502407
The human genome contains thousands of long noncoding RNAs (ncRNAs) transcribed from diverse genomic locations. A large set of long ncRNAs is transcribed independent of protein-coding genes. We have used...
5.
Lo W, Duggan L, Emre N, Belotserkovskya R, Lane W, Shiekhattar R, et al.
Science
. 2001 Aug;
293(5532):1142-6.
PMID: 11498592
Modification of histones is an important element in the regulation of gene expression. Previous work suggested a link between acetylation and phosphorylation, but questioned its mechanistic basis. We have purified...
6.
Marmorstein L, Kinev A, Chan G, Bochar D, Beniya H, Epstein J, et al.
Cell
. 2001 Feb;
104(2):247-57.
PMID: 11207365
Germline mutations of the human BRCA2 gene confer susceptibility to breast cancer. Although the function of the BRCA2 protein remains to be determined, murine cells homozygous for BRCA2 inactivation display...
7.
Bochar D, Wang L, Beniya H, Kinev A, Xue Y, Lane W, et al.
Cell
. 2000 Aug;
102(2):257-65.
PMID: 10943845
Germline mutations in the tumor suppressor gene, BRCA1, predispose individuals to breast and ovarian cancers. Using a combination of affinity- and conventional chromatographic techniques, we have isolated a predominant form...
8.
Guenther M, Lane W, Fischle W, Verdin E, Lazar M, Shiekhattar R
Genes Dev
. 2000 May;
14(9):1048-57.
PMID: 10809664
The corepressor SMRT mediates repression by thyroid hormone receptor (TR) as well as other nuclear hormone receptors and transcription factors. Here we report the isolation of a novel SMRT-containing complex...
9.
Schang L, Hwang G, Dynlacht B, Speicher D, Bantly A, Schaffer P, et al.
J Biol Chem
. 2000 Feb;
275(9):6071-4.
PMID: 10692395
The activity of cyclin-dependent protein kinases (cdks) is physiologically regulated by phosphorylation, association with the specific cyclin subunits, and repression by specific cdk inhibitors. All three physiological regulatory mechanisms are...
10.
Bochar D, Savard J, Wang W, LaFleur D, Moore P, Cote J, et al.
Proc Natl Acad Sci U S A
. 2000 Feb;
97(3):1038-43.
PMID: 10655480
Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of...